Recommendations for performing, interpreting and reporting hydrogen deuterium exchange mass spectrometry (HDX-MS) experiments

Hydrogen deuterium exchange mass spectrometry (HDX-MS) is a powerful biophysical technique being increasingly applied to a wide variety of problems. As the HDX-MS community continues to grow, adoption of best practices in data collection, analysis, presentation and interpretation will greatly enhanc...

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Autores principales: Masson, Glenn R., Burke, John E., Ahn, Natalie G., Anand, Ganesh S., Borchers, Christoph, Brier, Sébastien, Bou-Assaf, George M., Engen, John R., Englander, S. Walter, Faber, Johan, Garlish, Rachel, Griffin, Patrick R., Gross, Michael L., Guttman, Miklos, Hamuro, Yoshitomo, Heck, Albert J. R., Houde, Damian, Iacob, Roxana E., Jørgensen, Thomas J. D., Kaltashov, Igor A., Klinman, Judith P., Konermann, Lars, Man, Petr, Mayne, Leland, Pascal, Bruce D., Reichmann, Dana, Skehel, Mark, Snijder, Joost, Strutzenberg, Timothy S., Underbakke, Eric S., Wagner, Cornelia, Wales, Thomas E., Walters, Benjamin T., Weis, David D., Wilson, Derek J., Wintrode, Patrick L., Zhang, Zhongqi, Zheng, Jie, Schriemer, David C., Rand, Kasper D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group US 2019
Materias:
Perspective
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6614034/
https://www.ncbi.nlm.nih.gov/pubmed/31249422
http://dx.doi.org/10.1038/s41592-019-0459-y
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author Masson, Glenn R.
Burke, John E.
Ahn, Natalie G.
Anand, Ganesh S.
Borchers, Christoph
Brier, Sébastien
Bou-Assaf, George M.
Engen, John R.
Englander, S. Walter
Faber, Johan
Garlish, Rachel
Griffin, Patrick R.
Gross, Michael L.
Guttman, Miklos
Hamuro, Yoshitomo
Heck, Albert J. R.
Houde, Damian
Iacob, Roxana E.
Jørgensen, Thomas J. D.
Kaltashov, Igor A.
Klinman, Judith P.
Konermann, Lars
Man, Petr
Mayne, Leland
Pascal, Bruce D.
Reichmann, Dana
Skehel, Mark
Snijder, Joost
Strutzenberg, Timothy S.
Underbakke, Eric S.
Wagner, Cornelia
Wales, Thomas E.
Walters, Benjamin T.
Weis, David D.
Wilson, Derek J.
Wintrode, Patrick L.
Zhang, Zhongqi
Zheng, Jie
Schriemer, David C.
Rand, Kasper D.
author_facet Masson, Glenn R.
Burke, John E.
Ahn, Natalie G.
Anand, Ganesh S.
Borchers, Christoph
Brier, Sébastien
Bou-Assaf, George M.
Engen, John R.
Englander, S. Walter
Faber, Johan
Garlish, Rachel
Griffin, Patrick R.
Gross, Michael L.
Guttman, Miklos
Hamuro, Yoshitomo
Heck, Albert J. R.
Houde, Damian
Iacob, Roxana E.
Jørgensen, Thomas J. D.
Kaltashov, Igor A.
Klinman, Judith P.
Konermann, Lars
Man, Petr
Mayne, Leland
Pascal, Bruce D.
Reichmann, Dana
Skehel, Mark
Snijder, Joost
Strutzenberg, Timothy S.
Underbakke, Eric S.
Wagner, Cornelia
Wales, Thomas E.
Walters, Benjamin T.
Weis, David D.
Wilson, Derek J.
Wintrode, Patrick L.
Zhang, Zhongqi
Zheng, Jie
Schriemer, David C.
Rand, Kasper D.
author_sort Masson, Glenn R.
collection PubMed
description Hydrogen deuterium exchange mass spectrometry (HDX-MS) is a powerful biophysical technique being increasingly applied to a wide variety of problems. As the HDX-MS community continues to grow, adoption of best practices in data collection, analysis, presentation and interpretation will greatly enhance the accessibility of this technique to nonspecialists. Here we provide recommendations arising from community discussions emerging out of the first International Conference on Hydrogen-Exchange Mass Spectrometry (IC-HDX; 2017). It is meant to represent both a consensus viewpoint and an opportunity to stimulate further additions and refinements as the field advances.
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spelling pubmed-66140342019-07-08 Recommendations for performing, interpreting and reporting hydrogen deuterium exchange mass spectrometry (HDX-MS) experiments Masson, Glenn R. Burke, John E. Ahn, Natalie G. Anand, Ganesh S. Borchers, Christoph Brier, Sébastien Bou-Assaf, George M. Engen, John R. Englander, S. Walter Faber, Johan Garlish, Rachel Griffin, Patrick R. Gross, Michael L. Guttman, Miklos Hamuro, Yoshitomo Heck, Albert J. R. Houde, Damian Iacob, Roxana E. Jørgensen, Thomas J. D. Kaltashov, Igor A. Klinman, Judith P. Konermann, Lars Man, Petr Mayne, Leland Pascal, Bruce D. Reichmann, Dana Skehel, Mark Snijder, Joost Strutzenberg, Timothy S. Underbakke, Eric S. Wagner, Cornelia Wales, Thomas E. Walters, Benjamin T. Weis, David D. Wilson, Derek J. Wintrode, Patrick L. Zhang, Zhongqi Zheng, Jie Schriemer, David C. Rand, Kasper D. Nat Methods Perspective Hydrogen deuterium exchange mass spectrometry (HDX-MS) is a powerful biophysical technique being increasingly applied to a wide variety of problems. As the HDX-MS community continues to grow, adoption of best practices in data collection, analysis, presentation and interpretation will greatly enhance the accessibility of this technique to nonspecialists. Here we provide recommendations arising from community discussions emerging out of the first International Conference on Hydrogen-Exchange Mass Spectrometry (IC-HDX; 2017). It is meant to represent both a consensus viewpoint and an opportunity to stimulate further additions and refinements as the field advances. Nature Publishing Group US 2019-06-27 2019 /pmc/articles/PMC6614034/ /pubmed/31249422 http://dx.doi.org/10.1038/s41592-019-0459-y Text en © The Author(s) 2019 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
spellingShingle Perspective
Masson, Glenn R.
Burke, John E.
Ahn, Natalie G.
Anand, Ganesh S.
Borchers, Christoph
Brier, Sébastien
Bou-Assaf, George M.
Engen, John R.
Englander, S. Walter
Faber, Johan
Garlish, Rachel
Griffin, Patrick R.
Gross, Michael L.
Guttman, Miklos
Hamuro, Yoshitomo
Heck, Albert J. R.
Houde, Damian
Iacob, Roxana E.
Jørgensen, Thomas J. D.
Kaltashov, Igor A.
Klinman, Judith P.
Konermann, Lars
Man, Petr
Mayne, Leland
Pascal, Bruce D.
Reichmann, Dana
Skehel, Mark
Snijder, Joost
Strutzenberg, Timothy S.
Underbakke, Eric S.
Wagner, Cornelia
Wales, Thomas E.
Walters, Benjamin T.
Weis, David D.
Wilson, Derek J.
Wintrode, Patrick L.
Zhang, Zhongqi
Zheng, Jie
Schriemer, David C.
Rand, Kasper D.
Recommendations for performing, interpreting and reporting hydrogen deuterium exchange mass spectrometry (HDX-MS) experiments
title Recommendations for performing, interpreting and reporting hydrogen deuterium exchange mass spectrometry (HDX-MS) experiments
title_full Recommendations for performing, interpreting and reporting hydrogen deuterium exchange mass spectrometry (HDX-MS) experiments
title_fullStr Recommendations for performing, interpreting and reporting hydrogen deuterium exchange mass spectrometry (HDX-MS) experiments
title_full_unstemmed Recommendations for performing, interpreting and reporting hydrogen deuterium exchange mass spectrometry (HDX-MS) experiments
title_short Recommendations for performing, interpreting and reporting hydrogen deuterium exchange mass spectrometry (HDX-MS) experiments
title_sort recommendations for performing, interpreting and reporting hydrogen deuterium exchange mass spectrometry (hdx-ms) experiments
topic Perspective
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6614034/
https://www.ncbi.nlm.nih.gov/pubmed/31249422
http://dx.doi.org/10.1038/s41592-019-0459-y
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