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Genomics of the OLIG family of a bHLH transcription factor associated with oligo dendrogenesis
The glial cell neoplasms are not fully classified by using cellular morphology. However, this is possible using known molecular markers in glial development. Oligo-dendrocyte lineage gene induces differentiation of neural progenitors and putative immature progenitor cells of the adult central nervou...
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Biomedical Informatics
2019
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6614118/ https://www.ncbi.nlm.nih.gov/pubmed/31312081 http://dx.doi.org/10.6026/97320630015430 |
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author | Choudhury, Shouhartha |
author_facet | Choudhury, Shouhartha |
author_sort | Choudhury, Shouhartha |
collection | PubMed |
description | The glial cell neoplasms are not fully classified by using cellular morphology. However, this is possible using known molecular markers in glial development. Oligo-dendrocyte lineage gene induces differentiation of neural progenitors and putative immature progenitor cells of the adult central nervous system. These oligo-dendrocyte lineage genes OLIG1 and OLIG2 encode basic helix-loop-helix transcription factors. The murine bHLH transcription factors found in chromosome 21 are essential for oligo-dendrocyte development. Moreover, OLIG3 of the OLIG family is known to be linked with the brain and spinal cord development. Therefore, it is of interest to analyse oligodendrocyte lineage genes in the OLIG family of bHLH domain for the understanding of oligo-dendrogenesis in eukaryotes. Several bHLH domain linked basic-helix-loop-helix transcription factors in Homo sapiens and Mus musculus from this analysis are reported. Thus, genomics data analysis of OLIG family of bHLH transcription factors help explain observed similarity and differences within the molecular evolutionary context and hence assess the functional significance of the distinct genetic blueprints |
format | Online Article Text |
id | pubmed-6614118 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | Biomedical Informatics |
record_format | MEDLINE/PubMed |
spelling | pubmed-66141182019-07-16 Genomics of the OLIG family of a bHLH transcription factor associated with oligo dendrogenesis Choudhury, Shouhartha Bioinformation Research Article The glial cell neoplasms are not fully classified by using cellular morphology. However, this is possible using known molecular markers in glial development. Oligo-dendrocyte lineage gene induces differentiation of neural progenitors and putative immature progenitor cells of the adult central nervous system. These oligo-dendrocyte lineage genes OLIG1 and OLIG2 encode basic helix-loop-helix transcription factors. The murine bHLH transcription factors found in chromosome 21 are essential for oligo-dendrocyte development. Moreover, OLIG3 of the OLIG family is known to be linked with the brain and spinal cord development. Therefore, it is of interest to analyse oligodendrocyte lineage genes in the OLIG family of bHLH domain for the understanding of oligo-dendrogenesis in eukaryotes. Several bHLH domain linked basic-helix-loop-helix transcription factors in Homo sapiens and Mus musculus from this analysis are reported. Thus, genomics data analysis of OLIG family of bHLH transcription factors help explain observed similarity and differences within the molecular evolutionary context and hence assess the functional significance of the distinct genetic blueprints Biomedical Informatics 2019-06-15 /pmc/articles/PMC6614118/ /pubmed/31312081 http://dx.doi.org/10.6026/97320630015430 Text en © 2019 Biomedical Informatics http://creativecommons.org/licenses/by/3.0/ This is an Open Access article which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. This is distributed under the terms of the Creative Commons Attribution License. |
spellingShingle | Research Article Choudhury, Shouhartha Genomics of the OLIG family of a bHLH transcription factor associated with oligo dendrogenesis |
title | Genomics of the OLIG family of a bHLH transcription factor associated with oligo dendrogenesis |
title_full | Genomics of the OLIG family of a bHLH transcription factor associated with oligo dendrogenesis |
title_fullStr | Genomics of the OLIG family of a bHLH transcription factor associated with oligo dendrogenesis |
title_full_unstemmed | Genomics of the OLIG family of a bHLH transcription factor associated with oligo dendrogenesis |
title_short | Genomics of the OLIG family of a bHLH transcription factor associated with oligo dendrogenesis |
title_sort | genomics of the olig family of a bhlh transcription factor associated with oligo dendrogenesis |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6614118/ https://www.ncbi.nlm.nih.gov/pubmed/31312081 http://dx.doi.org/10.6026/97320630015430 |
work_keys_str_mv | AT choudhuryshouhartha genomicsoftheoligfamilyofabhlhtranscriptionfactorassociatedwitholigodendrogenesis |