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Phylogenetic insight of Nonribosomal peptide synthetases (NRPS) Adenylate domain in Antibacterial potential Streptomyces BDUSMP 02 isolated from Pitchavaram Mangrove

Identification of gene clusters in Streptomyces holds promise for the discovery of regulatory pathways linked to bioactive metabolites. We isolated a broad-spectrum antibacterial potential Streptomyces sp BDUSMP 02 from mangrove sediment. We further found a distinct of phylogeny pattern for NRPS A-d...

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Autores principales: Sivalingam, Periyasamy, Muthuselvam, Manickam, Pote, John, Prabakar, Kandasamy
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Biomedical Informatics 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6614122/
https://www.ncbi.nlm.nih.gov/pubmed/31312078
http://dx.doi.org/10.6026/97320630015412
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author Sivalingam, Periyasamy
Muthuselvam, Manickam
Pote, John
Prabakar, Kandasamy
author_facet Sivalingam, Periyasamy
Muthuselvam, Manickam
Pote, John
Prabakar, Kandasamy
author_sort Sivalingam, Periyasamy
collection PubMed
description Identification of gene clusters in Streptomyces holds promise for the discovery of regulatory pathways linked to bioactive metabolites. We isolated a broad-spectrum antibacterial potential Streptomyces sp BDUSMP 02 from mangrove sediment. We further found a distinct of phylogeny pattern for NRPS A-domain in the Streptomyces sp BDUSMP 02. The result suggests that Streptomyces sp BDUSMP 02 has the potential to produce a new type of antibacterial compounds belonging to NRPS type.
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spelling pubmed-66141222019-07-16 Phylogenetic insight of Nonribosomal peptide synthetases (NRPS) Adenylate domain in Antibacterial potential Streptomyces BDUSMP 02 isolated from Pitchavaram Mangrove Sivalingam, Periyasamy Muthuselvam, Manickam Pote, John Prabakar, Kandasamy Bioinformation Research Article Identification of gene clusters in Streptomyces holds promise for the discovery of regulatory pathways linked to bioactive metabolites. We isolated a broad-spectrum antibacterial potential Streptomyces sp BDUSMP 02 from mangrove sediment. We further found a distinct of phylogeny pattern for NRPS A-domain in the Streptomyces sp BDUSMP 02. The result suggests that Streptomyces sp BDUSMP 02 has the potential to produce a new type of antibacterial compounds belonging to NRPS type. Biomedical Informatics 2019-06-15 /pmc/articles/PMC6614122/ /pubmed/31312078 http://dx.doi.org/10.6026/97320630015412 Text en © 2019 Biomedical Informatics http://creativecommons.org/licenses/by/3.0/ This is an Open Access article which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. This is distributed under the terms of the Creative Commons Attribution License.
spellingShingle Research Article
Sivalingam, Periyasamy
Muthuselvam, Manickam
Pote, John
Prabakar, Kandasamy
Phylogenetic insight of Nonribosomal peptide synthetases (NRPS) Adenylate domain in Antibacterial potential Streptomyces BDUSMP 02 isolated from Pitchavaram Mangrove
title Phylogenetic insight of Nonribosomal peptide synthetases (NRPS) Adenylate domain in Antibacterial potential Streptomyces BDUSMP 02 isolated from Pitchavaram Mangrove
title_full Phylogenetic insight of Nonribosomal peptide synthetases (NRPS) Adenylate domain in Antibacterial potential Streptomyces BDUSMP 02 isolated from Pitchavaram Mangrove
title_fullStr Phylogenetic insight of Nonribosomal peptide synthetases (NRPS) Adenylate domain in Antibacterial potential Streptomyces BDUSMP 02 isolated from Pitchavaram Mangrove
title_full_unstemmed Phylogenetic insight of Nonribosomal peptide synthetases (NRPS) Adenylate domain in Antibacterial potential Streptomyces BDUSMP 02 isolated from Pitchavaram Mangrove
title_short Phylogenetic insight of Nonribosomal peptide synthetases (NRPS) Adenylate domain in Antibacterial potential Streptomyces BDUSMP 02 isolated from Pitchavaram Mangrove
title_sort phylogenetic insight of nonribosomal peptide synthetases (nrps) adenylate domain in antibacterial potential streptomyces bdusmp 02 isolated from pitchavaram mangrove
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6614122/
https://www.ncbi.nlm.nih.gov/pubmed/31312078
http://dx.doi.org/10.6026/97320630015412
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