Molecular docking based design of Dengue NS5 methyltransferase inhibitors

Dengue is a viral infection caused by RNA infection of the family Flaviviridae and spread by the Aedes mosquitoes. Dengue NS5 methyltransferase is a known drug target for the disease. Therefore, it is of interest to design potential inhibitors for the target using molecular docking analysis. Our ana...

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Detalles Bibliográficos
Autores principales: Kausar, Mohd Adnan, Ali, Abrar, Qiblawi, Samir, Shahid, SMA, Izhari, Mohammad Asrar, saral, Anamika
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Biomedical Informatics 2019
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6614123/
https://www.ncbi.nlm.nih.gov/pubmed/31312076
http://dx.doi.org/10.6026/97320630015394
Descripción
Sumario:Dengue is a viral infection caused by RNA infection of the family Flaviviridae and spread by the Aedes mosquitoes. Dengue NS5 methyltransferase is a known drug target for the disease. Therefore, it is of interest to design potential inhibitors for the target using molecular docking analysis. Our analysis shows the binding of compounds STOCK1N-98943, STOCK1N-98872, STOCK1N-98956, STOCK1N-98865, and STOCK1N-98950 with the protein drug target with optimal binding features for further in vitro and in vivo evaluations.

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