Cargando…

Molecular docking based design of Dengue NS5 methyltransferase inhibitors

Dengue is a viral infection caused by RNA infection of the family Flaviviridae and spread by the Aedes mosquitoes. Dengue NS5 methyltransferase is a known drug target for the disease. Therefore, it is of interest to design potential inhibitors for the target using molecular docking analysis. Our ana...

Descripción completa

Detalles Bibliográficos
Autores principales:	Kausar, Mohd Adnan, Ali, Abrar, Qiblawi, Samir, Shahid, SMA, Izhari, Mohammad Asrar, saral, Anamika
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Biomedical Informatics 2019
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6614123/ https://www.ncbi.nlm.nih.gov/pubmed/31312076 http://dx.doi.org/10.6026/97320630015394

Ejemplares similares

Designing cyclopentapeptide inhibitor as potential antiviral drug for dengue virus ns5 methyltransferase
por: Idrus, Syarifuddin, et al.
Publicado: (2012)

Screening of commercial cyclic peptide as inhibitor NS5 methyltransferase of Dengue virus through Molecular Docking and Molecular Dynamics Simulation
por: Tambunan, Usman Sumo Friend, et al.
Publicado: (2014)

Designing cyclic peptide inhibitor of dengue virus NS3-NS2B protease by using molecular docking approach
por: Tambunan, Usman Sumo Friend, et al.
Publicado: (2010)

Molecular Docking Based Screening of Plant Flavonoids as Dengue NS1 Inhibitors
por: Qamar, Muhammad Tahir ul, et al.
Publicado: (2014)

Inhibitor designing, virtual screening, and docking studies for methyltransferase: A potential target against dengue virus
por: Singh, Jagbir, et al.
Publicado: (2016)

Molecular Mechanisms of Resistance to Direct-Acting Antiviral (DAA) Drugs for the Treatment of Hepatitis C Virus Infections
por: Izhari, Mohammad Asrar
Publicado: (2023)

The data on molecular docking of cinnamic acid amide on dengue viral target NS2B/NS3
por: Yusoff, Nadia Mohamed, et al.
Publicado: (2022)

Design of New Competitive Dengue Ns2b/Ns3 Protease Inhibitors—A Computational Approach
por: Frimayanti, Neni, et al.
Publicado: (2011)

Identification and Characterization of Zika Virus NS5 Methyltransferase Inhibitors
por: Song, Weibao, et al.
Publicado: (2021)

Looking for inhibitors of the dengue virus NS5 RNA-dependent RNA-polymerase using a molecular docking approach
por: Galiano, Vicente, et al.
Publicado: (2016)

Seawater fungi-derived compound screening to identify novel small molecules against dengue virus NS5 methyltransferase and NS2B/NS3 protease
por: Hasan, Mahamudul, et al.
Publicado: (2022)

Evaluation of Melongosides as Potential Inhibitors of NS2B-NS3 Activator-Protease of Dengue Virus (Serotype 2) by Using Molecular Docking and Dynamics Simulation Approach
por: Biswas, Partha, et al.
Publicado: (2022)

Identification of new inhibitors of NS5 from dengue virus using saturation transfer difference (STD-NMR) and molecular docking studies
por: Ullah, Asmat, et al.
Publicado: (2022)

NS3 protease from flavivirus as a target for designing antiviral inhibitors against dengue virus
por: Natarajan, Satheesh
Publicado: (2010)

Design, Synthesis, Evaluation and Molecular Dynamics Simulation of Dengue Virus NS5-RdRp Inhibitors
por: Zong, Keli, et al.
Publicado: (2023)

Design, Synthesis and Discovery of N,N’‐Carbazoyl‐aryl‐urea Inhibitors of Zika NS5 Methyltransferase and Virus Replication
por: Spizzichino, Sharon, et al.
Publicado: (2020)

Structure-based and ligand-based virtual screening of novel methyltransferase inhibitors of the dengue virus
por: Lim, See Ven, et al.
Publicado: (2011)

The methyltransferase domain of dengue virus protein NS5 ensures efficient RNA synthesis initiation and elongation by the polymerase domain
por: Potisopon, Supanee, et al.
Publicado: (2014)

Dengue Virus Nonstructural Protein 5 (NS5) Assembles into a Dimer with a Unique Methyltransferase and Polymerase Interface
por: Klema, Valerie J., et al.
Publicado: (2016)

The methyltransferase domain of dengue virus protein NS5 ensures efficient RNA synthesis initiation and elongation by the polymerase domain
por: Potisopon, Supanee, et al.
Publicado: (2016)

New oxindole carboxamides as inhibitors of DENV NS5 RdRp: Design, synthesis, docking and Biochemical characterization
por: Koraboina, Chandra Prakash, et al.
Publicado: (2023)

Modification of S-Adenosyl-l-Homocysteine as Inhibitor of Nonstructural Protein 5 Methyltransferase Dengue Virus Through Molecular Docking and Molecular Dynamics Simulation
por: Tambunan, Usman Sumo Friend, et al.
Publicado: (2017)

Structures of NS5 Methyltransferase from Zika Virus
por: Coloma, Javier, et al.
Publicado: (2016)

Discovery of Ganoderma lucidum triterpenoids as potential inhibitors against Dengue virus NS2B-NS3 protease
por: Bharadwaj, Shiv, et al.
Publicado: (2019)

Computational study of nitro-benzylidene phenazine as dengue virus-2 NS2B-NS3 protease inhibitor
por: Salin, Nurul Hanim, et al.
Publicado: (2022)

In Vitro Evaluation of Novel Inhibitors against the NS2B-NS3 Protease of Dengue Fever Virus Type 4
por: Nguyen, Thi Thanh Hanh, et al.
Publicado: (2013)

An Approach for Systems-Level Understanding of Prostate Cancer from High-Throughput Data Integration to Pathway Modeling and Simulation
por: Mobashir, Mohammad, et al.
Publicado: (2022)

Molecular docking studies for the identification of novel melatoninergic inhibitors for acetylserotonin-O-methyltransferase using different docking routines
por: Azam, Syed Sikander, et al.
Publicado: (2013)

Structure‐Based Macrocyclization of Substrate Analogue NS2B‐NS3 Protease Inhibitors of Zika, West Nile and Dengue viruses
por: Braun, Niklas J., et al.
Publicado: (2020)

A Computational Approach Applied to the Study of Potential Allosteric Inhibitors Protease NS2B/NS3 from Dengue Virus
por: da Costa, Renato A., et al.
Publicado: (2022)

Evaluation of quercetin as a potential β-lactamase CTX-M-15 inhibitor via the molecular docking, dynamics simulations, and MMGBSA
por: SARIYER*, Emrah, et al.
Publicado: (2021)

Discovery of Terpenes as Novel HCV NS5B Polymerase Inhibitors via Molecular Docking
por: Karpiński, Tomasz M., et al.
Publicado: (2023)

Molecular Docking of Known Carcinogen 4- (Methyl-nitrosamino)-1-(3-pyridyl)-1-butanone (NNK) with Cyclin Dependent Kinases towards Its Potential Role in Cell Cycle Perturbation
por: Haneef, Mohd, et al.
Publicado: (2014)

Performance of commercial dengue NS1 ELISA and molecular analysis of NS1 gene of dengue viruses obtained during surveillance in Indonesia
por: Aryati, Aryati, et al.
Publicado: (2013)

Assessing the potential of NS2B/NS3 protease inhibitors biomarker in curbing dengue virus infections: In silico vs. In vitro approach
por: Norshidah, Harun, et al.
Publicado: (2023)

2′-O Methylation of Internal Adenosine by Flavivirus NS5 Methyltransferase
por: Dong, Hongping, et al.
Publicado: (2012)

The Interface between Methyltransferase and Polymerase of NS5 Is Essential for Flavivirus Replication
por: Li, Xiao-Dan, et al.
Publicado: (2014)

Rationalization of Activity Cliffs of a Sulfonamide Inhibitor of DNA Methyltransferases with Induced-Fit Docking
por: Medina-Franco, José L., et al.
Publicado: (2014)

Homology Modeling, de Novo Design of Ligands, and Molecular Docking Identify Potential Inhibitors of Leishmania donovani 24-Sterol Methyltransferase
por: Sakyi, Patrick O., et al.
Publicado: (2022)

Potent Allosteric Dengue Virus NS5 Polymerase Inhibitors: Mechanism of Action and Resistance Profiling
por: Lim, Siew Pheng, et al.
Publicado: (2016)

Cannot write session to /tmp/vufind_sessions/sess_1f5lage0f5gq0a7o6bn8k8plks