Unbound Fraction of Clozapine Significantly Decreases with Elevated Plasma Concentrations of the Inflammatory Acute-Phase Protein Alpha-1-Acid Glycoprotein

BACKGROUND: During inflammation, elevated total (unbound plus protein-bound) clozapine plasma concentrations have been observed. Elevated alpha-1-acid glycoprotein concentrations during inflammation are suggested to cause increased plasma clozapine-alpha-1-acid glycoprotein binding, resulting in ele...

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Detalles Bibliográficos
Autores principales: Man, Wai Hong, Wilting, Ingeborg, Heerdink, Eibert R., Hugenholtz, Gerard W. K., Bognár, Tim, ten Berg, Maarten J., van Solinge, Wouter W., Egberts, Toine A. C. G., van Maarseveen, Erik M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer International Publishing 2019
Materias:
Original Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6614135/
https://www.ncbi.nlm.nih.gov/pubmed/31111332
http://dx.doi.org/10.1007/s40262-019-00744-6

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