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Calibration of Novel Protein Biomarkers for Veterinary Clinical Pathology: A Call for International Action
Research into the identification and use of protein biomarkers for use in veterinary clinical pathology has produced numerous potential analytes that could become common tests in the future. One problem that has to be overcome in the general acceptance of a novel biomarker is that differing standard...
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Frontiers Media S.A.
2019
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6614203/ https://www.ncbi.nlm.nih.gov/pubmed/31312640 http://dx.doi.org/10.3389/fvets.2019.00210 |
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author | Eckersall, Peter David |
author_facet | Eckersall, Peter David |
author_sort | Eckersall, Peter David |
collection | PubMed |
description | Research into the identification and use of protein biomarkers for use in veterinary clinical pathology has produced numerous potential analytes that could become common tests in the future. One problem that has to be overcome in the general acceptance of a novel biomarker is that differing standards for calibration may be developed by individual laboratories or the diagnostic companies that will provide kits for widespread use. This has been apparent in the development of acute phase protein biomarkers such as canine C-reactive protein. In order to overcome this problem an international initiative is required to ensure that assays developed in separate laboratories would have a consistent calibration protocol so that results produced are equivalent. International reference preparations for serum protein analysis for each relevant species should be established for use as primary standard in the calibration of biomarkers for veterinary diagnosis. |
format | Online Article Text |
id | pubmed-6614203 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-66142032019-07-16 Calibration of Novel Protein Biomarkers for Veterinary Clinical Pathology: A Call for International Action Eckersall, Peter David Front Vet Sci Veterinary Science Research into the identification and use of protein biomarkers for use in veterinary clinical pathology has produced numerous potential analytes that could become common tests in the future. One problem that has to be overcome in the general acceptance of a novel biomarker is that differing standards for calibration may be developed by individual laboratories or the diagnostic companies that will provide kits for widespread use. This has been apparent in the development of acute phase protein biomarkers such as canine C-reactive protein. In order to overcome this problem an international initiative is required to ensure that assays developed in separate laboratories would have a consistent calibration protocol so that results produced are equivalent. International reference preparations for serum protein analysis for each relevant species should be established for use as primary standard in the calibration of biomarkers for veterinary diagnosis. Frontiers Media S.A. 2019-07-02 /pmc/articles/PMC6614203/ /pubmed/31312640 http://dx.doi.org/10.3389/fvets.2019.00210 Text en Copyright © 2019 Eckersall. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Veterinary Science Eckersall, Peter David Calibration of Novel Protein Biomarkers for Veterinary Clinical Pathology: A Call for International Action |
title | Calibration of Novel Protein Biomarkers for Veterinary Clinical Pathology: A Call for International Action |
title_full | Calibration of Novel Protein Biomarkers for Veterinary Clinical Pathology: A Call for International Action |
title_fullStr | Calibration of Novel Protein Biomarkers for Veterinary Clinical Pathology: A Call for International Action |
title_full_unstemmed | Calibration of Novel Protein Biomarkers for Veterinary Clinical Pathology: A Call for International Action |
title_short | Calibration of Novel Protein Biomarkers for Veterinary Clinical Pathology: A Call for International Action |
title_sort | calibration of novel protein biomarkers for veterinary clinical pathology: a call for international action |
topic | Veterinary Science |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6614203/ https://www.ncbi.nlm.nih.gov/pubmed/31312640 http://dx.doi.org/10.3389/fvets.2019.00210 |
work_keys_str_mv | AT eckersallpeterdavid calibrationofnovelproteinbiomarkersforveterinaryclinicalpathologyacallforinternationalaction |