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Correlation of CD4/CD8 Ratio with Carotid Intima-Media Layer Thickness in HIV/AIDS Patients at Sanglah General Hospital, Bali, Indonesia
BACKGROUND: The discovery of antiretroviral (ARV) drugs in 1996 led to a shift in the causes of mortality and morbidity of patients with HIV/AIDS. Initially, the cause of mortality and morbidity was associated with opportunistic infection HIV/AIDS-related complication, but now are more associated wi...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Republic of Macedonia
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6614274/ https://www.ncbi.nlm.nih.gov/pubmed/31316662 http://dx.doi.org/10.3889/oamjms.2019.479 |
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author | Utama, Susila Patriawan, Putu Dewi, Aryanti |
author_facet | Utama, Susila Patriawan, Putu Dewi, Aryanti |
author_sort | Utama, Susila |
collection | PubMed |
description | BACKGROUND: The discovery of antiretroviral (ARV) drugs in 1996 led to a shift in the causes of mortality and morbidity of patients with HIV/AIDS. Initially, the cause of mortality and morbidity was associated with opportunistic infection HIV/AIDS-related complication, but now are more associated with non-AIDS complication such as cardiovascular disease. Atherosclerosis is a major cause of cardiovascular disease. The atherosclerosis was assessed by measuring carotid intima-media thickness (CIMT) using B mode ultrasound (USG), which is one of the diagnostic tools in indicating the presence of atherosclerotic plaque. AIM: This study aims to evaluate the ratio of CD4 / CD8 towards carotid intima-media thickness. METHODS: Design of study was analytic cross-sectional. This study was conducted in May – July 2017 in HIV patients who taken consecutively came to the VCT polyclinic of Sanglah hospital. Statistical analysis used Spearman correlation test to evaluate the correlation between the CD4/CD8 ratio and carotid intima-media thickness and multiple linear regression to predict carotid intima-media thickness through CD4/CD8 ratio. RESULTS: Total from 50 samples, data characteristic were 33 males (66%) and 17 females (34%), mean of age 30.60 ± 5.58 years, median of CD4/CD8 ratio 0.275 (0.02-1.39) and median of CIMT 0.75 (0.4-1.5) mm. There is a strong negative correlation (r = -0.85; p = 0.001) CD4/CD8 ratio with CIMT. The calculation of the prediction of carotid intima media thickness can be calculated through the equation Y = 0.727 -0.791 (X1) + 0.012 (X2), where X1 is CD4/CD8 ratio and X2 is the age of the patient. CONCLUSION: there is a significantly strong negative correlation between the CD4/CD8 ratio and CIMT in HIV patient who comes to VCT polyclinic of Sanglah Hospital. The smaller CD4/CD8 ratio, the value of CIMT will be thicker, and vice versa. |
format | Online Article Text |
id | pubmed-6614274 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | Republic of Macedonia |
record_format | MEDLINE/PubMed |
spelling | pubmed-66142742019-07-17 Correlation of CD4/CD8 Ratio with Carotid Intima-Media Layer Thickness in HIV/AIDS Patients at Sanglah General Hospital, Bali, Indonesia Utama, Susila Patriawan, Putu Dewi, Aryanti Open Access Maced J Med Sci Clinical Science BACKGROUND: The discovery of antiretroviral (ARV) drugs in 1996 led to a shift in the causes of mortality and morbidity of patients with HIV/AIDS. Initially, the cause of mortality and morbidity was associated with opportunistic infection HIV/AIDS-related complication, but now are more associated with non-AIDS complication such as cardiovascular disease. Atherosclerosis is a major cause of cardiovascular disease. The atherosclerosis was assessed by measuring carotid intima-media thickness (CIMT) using B mode ultrasound (USG), which is one of the diagnostic tools in indicating the presence of atherosclerotic plaque. AIM: This study aims to evaluate the ratio of CD4 / CD8 towards carotid intima-media thickness. METHODS: Design of study was analytic cross-sectional. This study was conducted in May – July 2017 in HIV patients who taken consecutively came to the VCT polyclinic of Sanglah hospital. Statistical analysis used Spearman correlation test to evaluate the correlation between the CD4/CD8 ratio and carotid intima-media thickness and multiple linear regression to predict carotid intima-media thickness through CD4/CD8 ratio. RESULTS: Total from 50 samples, data characteristic were 33 males (66%) and 17 females (34%), mean of age 30.60 ± 5.58 years, median of CD4/CD8 ratio 0.275 (0.02-1.39) and median of CIMT 0.75 (0.4-1.5) mm. There is a strong negative correlation (r = -0.85; p = 0.001) CD4/CD8 ratio with CIMT. The calculation of the prediction of carotid intima media thickness can be calculated through the equation Y = 0.727 -0.791 (X1) + 0.012 (X2), where X1 is CD4/CD8 ratio and X2 is the age of the patient. CONCLUSION: there is a significantly strong negative correlation between the CD4/CD8 ratio and CIMT in HIV patient who comes to VCT polyclinic of Sanglah Hospital. The smaller CD4/CD8 ratio, the value of CIMT will be thicker, and vice versa. Republic of Macedonia 2019-06-13 /pmc/articles/PMC6614274/ /pubmed/31316662 http://dx.doi.org/10.3889/oamjms.2019.479 Text en Copyright: © 2019 Susila Utama, Putu Patriawan, Aryanti Dewi. http://creativecommons.org/licenses/CC BY-NC/4.0 This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (CC BY-NC 4.0). |
spellingShingle | Clinical Science Utama, Susila Patriawan, Putu Dewi, Aryanti Correlation of CD4/CD8 Ratio with Carotid Intima-Media Layer Thickness in HIV/AIDS Patients at Sanglah General Hospital, Bali, Indonesia |
title | Correlation of CD4/CD8 Ratio with Carotid Intima-Media Layer Thickness in HIV/AIDS Patients at Sanglah General Hospital, Bali, Indonesia |
title_full | Correlation of CD4/CD8 Ratio with Carotid Intima-Media Layer Thickness in HIV/AIDS Patients at Sanglah General Hospital, Bali, Indonesia |
title_fullStr | Correlation of CD4/CD8 Ratio with Carotid Intima-Media Layer Thickness in HIV/AIDS Patients at Sanglah General Hospital, Bali, Indonesia |
title_full_unstemmed | Correlation of CD4/CD8 Ratio with Carotid Intima-Media Layer Thickness in HIV/AIDS Patients at Sanglah General Hospital, Bali, Indonesia |
title_short | Correlation of CD4/CD8 Ratio with Carotid Intima-Media Layer Thickness in HIV/AIDS Patients at Sanglah General Hospital, Bali, Indonesia |
title_sort | correlation of cd4/cd8 ratio with carotid intima-media layer thickness in hiv/aids patients at sanglah general hospital, bali, indonesia |
topic | Clinical Science |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6614274/ https://www.ncbi.nlm.nih.gov/pubmed/31316662 http://dx.doi.org/10.3889/oamjms.2019.479 |
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