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miRNA-Directed Regulation of the Main Signaling Pathways in Thyroid Cancer
In the last two decades, great strides have been made in the study of microRNAs in development and in diseases such as cancer, as reflected in the exponential increase in the number of reviews on this topic including those on undifferentiated and well-differentiated thyroid cancer. Nevertheless, few...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2019
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6614345/ https://www.ncbi.nlm.nih.gov/pubmed/31312183 http://dx.doi.org/10.3389/fendo.2019.00430 |
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author | Ramírez-Moya, Julia Santisteban, Pilar |
author_facet | Ramírez-Moya, Julia Santisteban, Pilar |
author_sort | Ramírez-Moya, Julia |
collection | PubMed |
description | In the last two decades, great strides have been made in the study of microRNAs in development and in diseases such as cancer, as reflected in the exponential increase in the number of reviews on this topic including those on undifferentiated and well-differentiated thyroid cancer. Nevertheless, few reviews have focused on understanding the functional significance of the most up- or down-regulated miRNAs in thyroid cancer for the main signaling pathways hyperactivated in this tumor type. The aim of this review is to discuss the major miRNAs targeting proteins of the MAPK, PI3K, and TGFβ pathways, to define their mechanisms of action through the 3′UTR regions of their target genes, and to describe how they affect thyroid tumorigenesis through their actions on cell proliferation, migration, and invasion. Given the importance of miRNAs in cancer as diagnostic, prognostic and therapeutic candidates, a better understanding of this cross-talk might shed new light on the biomedical treatment of thyroid cancer. |
format | Online Article Text |
id | pubmed-6614345 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-66143452019-07-16 miRNA-Directed Regulation of the Main Signaling Pathways in Thyroid Cancer Ramírez-Moya, Julia Santisteban, Pilar Front Endocrinol (Lausanne) Endocrinology In the last two decades, great strides have been made in the study of microRNAs in development and in diseases such as cancer, as reflected in the exponential increase in the number of reviews on this topic including those on undifferentiated and well-differentiated thyroid cancer. Nevertheless, few reviews have focused on understanding the functional significance of the most up- or down-regulated miRNAs in thyroid cancer for the main signaling pathways hyperactivated in this tumor type. The aim of this review is to discuss the major miRNAs targeting proteins of the MAPK, PI3K, and TGFβ pathways, to define their mechanisms of action through the 3′UTR regions of their target genes, and to describe how they affect thyroid tumorigenesis through their actions on cell proliferation, migration, and invasion. Given the importance of miRNAs in cancer as diagnostic, prognostic and therapeutic candidates, a better understanding of this cross-talk might shed new light on the biomedical treatment of thyroid cancer. Frontiers Media S.A. 2019-07-02 /pmc/articles/PMC6614345/ /pubmed/31312183 http://dx.doi.org/10.3389/fendo.2019.00430 Text en Copyright © 2019 Ramírez-Moya and Santisteban. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Endocrinology Ramírez-Moya, Julia Santisteban, Pilar miRNA-Directed Regulation of the Main Signaling Pathways in Thyroid Cancer |
title | miRNA-Directed Regulation of the Main Signaling Pathways in Thyroid Cancer |
title_full | miRNA-Directed Regulation of the Main Signaling Pathways in Thyroid Cancer |
title_fullStr | miRNA-Directed Regulation of the Main Signaling Pathways in Thyroid Cancer |
title_full_unstemmed | miRNA-Directed Regulation of the Main Signaling Pathways in Thyroid Cancer |
title_short | miRNA-Directed Regulation of the Main Signaling Pathways in Thyroid Cancer |
title_sort | mirna-directed regulation of the main signaling pathways in thyroid cancer |
topic | Endocrinology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6614345/ https://www.ncbi.nlm.nih.gov/pubmed/31312183 http://dx.doi.org/10.3389/fendo.2019.00430 |
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