Chemical genomics reveals histone deacetylases are required for core regulatory transcription

Identity determining transcription factors (TFs), or core regulatory (CR) TFs, are governed by cell-type specific super enhancers (SEs). Drugs to selectively inhibit CR circuitry are of high interest for cancer treatment. In alveolar rhabdomyosarcoma, PAX3-FOXO1 activates SEs to induce the expressio...

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Detalles Bibliográficos
Autores principales: Gryder, Berkley E., Wu, Lei, Woldemichael, Girma M., Pomella, Silvia, Quinn, Taylor R., Park, Paul M. C., Cleveland, Abigail, Stanton, Benjamin Z., Song, Young, Rota, Rossella, Wiest, Olaf, Yohe, Marielle E., Shern, Jack F., Qi, Jun, Khan, Javed
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6614369/
https://www.ncbi.nlm.nih.gov/pubmed/31285436
http://dx.doi.org/10.1038/s41467-019-11046-7

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