The mammalian CTLH complex is an E3 ubiquitin ligase that targets its subunit muskelin for degradation

The multi-subunit C-terminal to LisH (CTLH) complex is the mammalian homologue of the yeast Gid E3 ubiquitin ligase complex. In this study, we investigated the human CTLH complex and characterized its E3 ligase activity. We confirm that the complex immunoprecipitated from human cells comprises RanBP...

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Detalles Bibliográficos
Autores principales: Maitland, Matthew E. R., Onea, Gabriel, Chiasson, Christopher A., Wang, Xu, Ma, Jun, Moor, Sarah E., Barber, Kathryn R., Lajoie, Gilles A., Shaw, Gary S., Schild-Poulter, Caroline
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6614414/
https://www.ncbi.nlm.nih.gov/pubmed/31285494
http://dx.doi.org/10.1038/s41598-019-46279-5

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