PGRN acts as a novel regulator of mitochondrial homeostasis by facilitating mitophagy and mitochondrial biogenesis to prevent podocyte injury in diabetic nephropathy

Mitochondrial dysfunction is considered as a key mediator in the pathogenesis of diabetic nephropathy (DN). Therapeutic strategies targeting mitochondrial dysfunction hold considerable promise for the treatment of DN. In this study, we investigated the role of progranulin (PGRN), a secreted glycopro...

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Detalles Bibliográficos
Autores principales: Zhou, Di, Zhou, Meng, Wang, Ziying, Fu, Yi, Jia, Meng, Wang, Xiaojie, Liu, Min, Zhang, Yan, Sun, Yu, Lu, Yi, Tang, Wei, Yi, Fan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6614416/
https://www.ncbi.nlm.nih.gov/pubmed/31285425
http://dx.doi.org/10.1038/s41419-019-1754-3

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