mTOR Signaling Upregulates CDC6 via Suppressing miR-3178 and Promotes the Loading of DNA Replication Helicase

mTOR signaling pathway is deregulated in most cancers and uncontrolled cell cycle progression is a hallmark of cancer cell. However, the precise molecular mechanisms of the regulation of DNA replication and chromatin metabolism by mTOR signaling are largely unknown. We herein report that mTOR signal...

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Detalles Bibliográficos
Autores principales: Wu, Xianjin, Li, Shenghua, Hu, Xing, Xiang, Xiaoliang, Halloran, Megan, Yang, Linlin, Williams, Terence M., Houghton, Peter J., Shen, Changxian, He, Zhengfu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6614418/
https://www.ncbi.nlm.nih.gov/pubmed/31285446
http://dx.doi.org/10.1038/s41598-019-46052-8

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6614418/
https://www.ncbi.nlm.nih.gov/pubmed/31285446
http://dx.doi.org/10.1038/s41598-019-46052-8

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