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mTOR Signaling Upregulates CDC6 via Suppressing miR-3178 and Promotes the Loading of DNA Replication Helicase

mTOR signaling pathway is deregulated in most cancers and uncontrolled cell cycle progression is a hallmark of cancer cell. However, the precise molecular mechanisms of the regulation of DNA replication and chromatin metabolism by mTOR signaling are largely unknown. We herein report that mTOR signal...

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Detalles Bibliográficos
Autores principales:	Wu, Xianjin, Li, Shenghua, Hu, Xing, Xiang, Xiaoliang, Halloran, Megan, Yang, Linlin, Williams, Terence M., Houghton, Peter J., Shen, Changxian, He, Zhengfu
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2019
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6614418/ https://www.ncbi.nlm.nih.gov/pubmed/31285446 http://dx.doi.org/10.1038/s41598-019-46052-8

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