High throughput development of TCR-mimic antibody that targets survivin-2B(80-88)/HLA-A*A24 and its application in a bispecific T-cell engager

Intracellular tumor-associated antigens are targeted by antibodies known as T-cell receptor mimic antibodies (TCRm-Abs), which recognize T-cell epitopes with better stabilities and higher affinities than T-cell receptors. However, TCRm-Abs have been proven difficult to produce using conventional tec...

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Detalles Bibliográficos
Autores principales: Kurosawa, Nobuyuki, Wakata, Yuka, Ida, Kenta, Midorikawa, Aki, Isobe, Masaharu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6614450/
https://www.ncbi.nlm.nih.gov/pubmed/31285464
http://dx.doi.org/10.1038/s41598-019-46198-5

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6614450/
https://www.ncbi.nlm.nih.gov/pubmed/31285464
http://dx.doi.org/10.1038/s41598-019-46198-5

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