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High throughput development of TCR-mimic antibody that targets survivin-2B(80-88)/HLA-A*A24 and its application in a bispecific T-cell engager
Intracellular tumor-associated antigens are targeted by antibodies known as T-cell receptor mimic antibodies (TCRm-Abs), which recognize T-cell epitopes with better stabilities and higher affinities than T-cell receptors. However, TCRm-Abs have been proven difficult to produce using conventional tec...
| Autores principales: | , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Nature Publishing Group UK
2019
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6614450/ https://www.ncbi.nlm.nih.gov/pubmed/31285464 http://dx.doi.org/10.1038/s41598-019-46198-5 |