AgBR1 antibodies delay lethal Aedes aegypti-borne West Nile virus infection in mice

West Nile virus (WNV) is transmitted by mosquitoes and can cause severe disease, including meningoencephalitis. AgBR1 is a mosquito salivary protein that enhances Aedes aegypti mosquito-borne Zika virus pathogenesis in mice. Here, we show that AgBR1 antibodies reduce the initial West Nile viral load...

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Autores principales: Uraki, Ryuta, Hastings, Andrew K., Brackney, Doug E., Armstrong, Philip M., Fikrig, Erol
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Brief Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6614468/
https://www.ncbi.nlm.nih.gov/pubmed/31312526
http://dx.doi.org/10.1038/s41541-019-0120-x
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author Uraki, Ryuta
Hastings, Andrew K.
Brackney, Doug E.
Armstrong, Philip M.
Fikrig, Erol
author_facet Uraki, Ryuta
Hastings, Andrew K.
Brackney, Doug E.
Armstrong, Philip M.
Fikrig, Erol
author_sort Uraki, Ryuta
collection PubMed
description West Nile virus (WNV) is transmitted by mosquitoes and can cause severe disease, including meningoencephalitis. AgBR1 is a mosquito salivary protein that enhances Aedes aegypti mosquito-borne Zika virus pathogenesis in mice. Here, we show that AgBR1 antibodies reduce the initial West Nile viral load and delay lethal infection after feeding by an infected Aedes aegypti mosquito. Targeting AgBR1 may therefore be incorporated into strategies to prevent mosquito-transmitted West Nile virus infection.
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spelling pubmed-66144682019-07-16 AgBR1 antibodies delay lethal Aedes aegypti-borne West Nile virus infection in mice Uraki, Ryuta Hastings, Andrew K. Brackney, Doug E. Armstrong, Philip M. Fikrig, Erol NPJ Vaccines Brief Communication West Nile virus (WNV) is transmitted by mosquitoes and can cause severe disease, including meningoencephalitis. AgBR1 is a mosquito salivary protein that enhances Aedes aegypti mosquito-borne Zika virus pathogenesis in mice. Here, we show that AgBR1 antibodies reduce the initial West Nile viral load and delay lethal infection after feeding by an infected Aedes aegypti mosquito. Targeting AgBR1 may therefore be incorporated into strategies to prevent mosquito-transmitted West Nile virus infection. Nature Publishing Group UK 2019-07-08 /pmc/articles/PMC6614468/ /pubmed/31312526 http://dx.doi.org/10.1038/s41541-019-0120-x Text en © The Author(s) 2019 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
spellingShingle Brief Communication
Uraki, Ryuta
Hastings, Andrew K.
Brackney, Doug E.
Armstrong, Philip M.
Fikrig, Erol
AgBR1 antibodies delay lethal Aedes aegypti-borne West Nile virus infection in mice
title AgBR1 antibodies delay lethal Aedes aegypti-borne West Nile virus infection in mice
title_full AgBR1 antibodies delay lethal Aedes aegypti-borne West Nile virus infection in mice
title_fullStr AgBR1 antibodies delay lethal Aedes aegypti-borne West Nile virus infection in mice
title_full_unstemmed AgBR1 antibodies delay lethal Aedes aegypti-borne West Nile virus infection in mice
title_short AgBR1 antibodies delay lethal Aedes aegypti-borne West Nile virus infection in mice
title_sort agbr1 antibodies delay lethal aedes aegypti-borne west nile virus infection in mice
topic Brief Communication
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6614468/
https://www.ncbi.nlm.nih.gov/pubmed/31312526
http://dx.doi.org/10.1038/s41541-019-0120-x
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