Blockade of L-type Ca(2+) channel attenuates doxorubicin-induced cardiomyopathy via suppression of CaMKII-NF-κB pathway

Ca(2+)/calmodulin-dependent protein kinase II (CaMKII) and nuclear factor-kappa B (NF-κB) play crucial roles in pathogenesis of doxorubicin (DOX)-induced cardiomyopathy. Their activities are regulated by intracellular Ca(2+). We hypothesized that blockade of L-type Ca(2+) channel (LTCC) could attenu...

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Detalles Bibliográficos
Autores principales: Ikeda, Soichiro, Matsushima, Shouji, Okabe, Kosuke, Ikeda, Masataka, Ishikita, Akihito, Tadokoro, Tomonori, Enzan, Nobuyuki, Yamamoto, Taishi, Sada, Masashi, Deguchi, Hiroko, Morimoto, Sachio, Ide, Tomomi, Tsutsui, Hiroyuki
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6614470/
https://www.ncbi.nlm.nih.gov/pubmed/31285514
http://dx.doi.org/10.1038/s41598-019-46367-6

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