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4-hydroxyphenylpyruvate dioxygenase promotes lung cancer growth via pentose phosphate pathway (PPP) flux mediated by LKB1-AMPK/HDAC10/G6PD axis

4-hydroxyphenylpyruvate dioxygenase (HPD) is an important modifier of tyrosine metabolism. However, the precise contribution of HPD to cancer metabolism and tumorigenesis remains unclear. In this study, we found that HPD was highly expressed in lung cancer and its higher expression correlated with p...

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Detalles Bibliográficos
Autores principales:	Shan, Changliang, Lu, Zhaoliang, Li, Zhen, Sheng, Hao, Fan, Jun, Qi, Qi, Liu, Shuangping, Zhang, Shuai
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2019
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6614486/ https://www.ncbi.nlm.nih.gov/pubmed/31285420 http://dx.doi.org/10.1038/s41419-019-1756-1

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