Cargando…

Electrophysiological Subtypes and Prognostic Factors of Guillain-Barre Syndrome in Northern China

Objectives: To assess the epidemiology of different electrophysiological subtypes of Guillain-Barre syndrome (GBS) and investigate the factors affecting the prognosis of the acute motor axonal neuropathy (AMAN) subtype in northern China. Methods: According to the National Institute of Neurological D...

Descripción completa

Detalles Bibliográficos
Autores principales: Tian, Jing, Cao, Cuifang, Li, Tong, Zhang, Kun, Li, Peifang, Liu, Yaling, Liu, Xiaoyun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6614537/
https://www.ncbi.nlm.nih.gov/pubmed/31333568
http://dx.doi.org/10.3389/fneur.2019.00714
_version_ 1783433206603710464
author Tian, Jing
Cao, Cuifang
Li, Tong
Zhang, Kun
Li, Peifang
Liu, Yaling
Liu, Xiaoyun
author_facet Tian, Jing
Cao, Cuifang
Li, Tong
Zhang, Kun
Li, Peifang
Liu, Yaling
Liu, Xiaoyun
author_sort Tian, Jing
collection PubMed
description Objectives: To assess the epidemiology of different electrophysiological subtypes of Guillain-Barre syndrome (GBS) and investigate the factors affecting the prognosis of the acute motor axonal neuropathy (AMAN) subtype in northern China. Methods: According to the National Institute of Neurological Disorders and Stroke diagnostic criteria for GBS, 104 consecutive GBS patients were recruited from the Department of Neurology of the Second Hospital of Hebei Medical University, China from 2014 to 2018. Results: Based on nerve conduction studies (NCSs), AMAN was the most common subtype in Northern China, accounting for 58 patients (55.8%). AMAN patients had significantly higher prevalence of antecedent diarrhea, longer duration of hospitalization, and slightly slower recovery than those with acute inflammatory demyelinating polyneuropathy (AIDP), but there was no statistical difference in disease severity or short-term prognosis between AMAN and AIDP. Based on multivariate regression analysis, AMAN patients with antecedent diarrhea (OR = 0.16, 95% CI: 0.03–0.756, p = 0.021) or conduction blocks (CBs) (OR = 0.033, 95% CI: 0.001–0.787, p = 0.035) had dramatically better short-term prognosis. Decreased compound action potential with distal stimulation (dCMAP) amplitude was associated with significant slower speed of recovery(OR = 8.31, 95% CI: 2.55–27.10, p = 0.02). Conclusion: AMAN is still the most common subtype of GBS in northern China. A decline in dCMAP amplitude is predictive factor of a slow recovery and poor outcome of GBS. Diarrhea and CBs may be the factors for better short-term prognosis in AMAN patients in Northern China.
format Online
Article
Text
id pubmed-6614537
institution National Center for Biotechnology Information
language English
publishDate 2019
publisher Frontiers Media S.A.
record_format MEDLINE/PubMed
spelling pubmed-66145372019-07-22 Electrophysiological Subtypes and Prognostic Factors of Guillain-Barre Syndrome in Northern China Tian, Jing Cao, Cuifang Li, Tong Zhang, Kun Li, Peifang Liu, Yaling Liu, Xiaoyun Front Neurol Neurology Objectives: To assess the epidemiology of different electrophysiological subtypes of Guillain-Barre syndrome (GBS) and investigate the factors affecting the prognosis of the acute motor axonal neuropathy (AMAN) subtype in northern China. Methods: According to the National Institute of Neurological Disorders and Stroke diagnostic criteria for GBS, 104 consecutive GBS patients were recruited from the Department of Neurology of the Second Hospital of Hebei Medical University, China from 2014 to 2018. Results: Based on nerve conduction studies (NCSs), AMAN was the most common subtype in Northern China, accounting for 58 patients (55.8%). AMAN patients had significantly higher prevalence of antecedent diarrhea, longer duration of hospitalization, and slightly slower recovery than those with acute inflammatory demyelinating polyneuropathy (AIDP), but there was no statistical difference in disease severity or short-term prognosis between AMAN and AIDP. Based on multivariate regression analysis, AMAN patients with antecedent diarrhea (OR = 0.16, 95% CI: 0.03–0.756, p = 0.021) or conduction blocks (CBs) (OR = 0.033, 95% CI: 0.001–0.787, p = 0.035) had dramatically better short-term prognosis. Decreased compound action potential with distal stimulation (dCMAP) amplitude was associated with significant slower speed of recovery(OR = 8.31, 95% CI: 2.55–27.10, p = 0.02). Conclusion: AMAN is still the most common subtype of GBS in northern China. A decline in dCMAP amplitude is predictive factor of a slow recovery and poor outcome of GBS. Diarrhea and CBs may be the factors for better short-term prognosis in AMAN patients in Northern China. Frontiers Media S.A. 2019-07-02 /pmc/articles/PMC6614537/ /pubmed/31333568 http://dx.doi.org/10.3389/fneur.2019.00714 Text en Copyright © 2019 Tian, Cao, Li, Zhang, Li, Liu and Liu. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Neurology
Tian, Jing
Cao, Cuifang
Li, Tong
Zhang, Kun
Li, Peifang
Liu, Yaling
Liu, Xiaoyun
Electrophysiological Subtypes and Prognostic Factors of Guillain-Barre Syndrome in Northern China
title Electrophysiological Subtypes and Prognostic Factors of Guillain-Barre Syndrome in Northern China
title_full Electrophysiological Subtypes and Prognostic Factors of Guillain-Barre Syndrome in Northern China
title_fullStr Electrophysiological Subtypes and Prognostic Factors of Guillain-Barre Syndrome in Northern China
title_full_unstemmed Electrophysiological Subtypes and Prognostic Factors of Guillain-Barre Syndrome in Northern China
title_short Electrophysiological Subtypes and Prognostic Factors of Guillain-Barre Syndrome in Northern China
title_sort electrophysiological subtypes and prognostic factors of guillain-barre syndrome in northern china
topic Neurology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6614537/
https://www.ncbi.nlm.nih.gov/pubmed/31333568
http://dx.doi.org/10.3389/fneur.2019.00714
work_keys_str_mv AT tianjing electrophysiologicalsubtypesandprognosticfactorsofguillainbarresyndromeinnorthernchina
AT caocuifang electrophysiologicalsubtypesandprognosticfactorsofguillainbarresyndromeinnorthernchina
AT litong electrophysiologicalsubtypesandprognosticfactorsofguillainbarresyndromeinnorthernchina
AT zhangkun electrophysiologicalsubtypesandprognosticfactorsofguillainbarresyndromeinnorthernchina
AT lipeifang electrophysiologicalsubtypesandprognosticfactorsofguillainbarresyndromeinnorthernchina
AT liuyaling electrophysiologicalsubtypesandprognosticfactorsofguillainbarresyndromeinnorthernchina
AT liuxiaoyun electrophysiologicalsubtypesandprognosticfactorsofguillainbarresyndromeinnorthernchina