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The Psychiatric Risk Gene NT5C2 Regulates Adenosine Monophosphate-Activated Protein Kinase Signaling and Protein Translation in Human Neural Progenitor Cells

BACKGROUND: The 5′-nucleotidase, cytosolic II gene (NT5C2, cN-II) is associated with disorders characterized by psychiatric and psychomotor disturbances. Common psychiatric risk alleles at the NT5C2 locus reduce expression of this gene in the fetal and adult brain, but downstream biological risk mec...

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Detalles Bibliográficos
Autores principales:	Duarte, Rodrigo R.R., Bachtel, Nathaniel D., Côtel, Marie-Caroline, Lee, Sang H., Selvackadunco, Sashika, Watson, Iain A., Hovsepian, Gary A., Troakes, Claire, Breen, Gerome D., Nixon, Douglas F., Murray, Robin M., Bray, Nicholas J., Eleftherianos, Ioannis, Vernon, Anthony C., Powell, Timothy R., Srivastava, Deepak P.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier 2019
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6614717/ https://www.ncbi.nlm.nih.gov/pubmed/31097295 http://dx.doi.org/10.1016/j.biopsych.2019.03.977

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