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The ATP-dependent chromatin remodelling enzyme Uls1 prevents Topoisomerase II poisoning

Topoisomerase II (Top2) is an essential enzyme that decatenates DNA via a transient Top2-DNA covalent intermediate. This intermediate can be stabilized by a class of drugs termed Top2 poisons, resulting in massive DNA damage. Thus, Top2 activity is a double-edged sword that needs to be carefully con...

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Detalles Bibliográficos
Autores principales:	Swanston, Amy, Zabrady, Katerina, Ferreira, Helder C
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2019
Materias:	Gene regulation, Chromatin and Epigenetics
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6614809/ https://www.ncbi.nlm.nih.gov/pubmed/31106359 http://dx.doi.org/10.1093/nar/gkz362

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