Thermodynamically stable and genetically unstable G-quadruplexes are depleted in genomes across species

G-quadruplexes play various roles in multiple biological processes, which can be positive when a G4 is involved in the regulation of gene expression or detrimental when the folding of a stable G4 impairs DNA replication promoting genome instability. This duality interrogates the significance of thei...

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Detalles Bibliográficos
Autores principales: Puig Lombardi, Emilia, Holmes, Allyson, Verga, Daniela, Teulade-Fichou, Marie-Paule, Nicolas, Alain, Londoño-Vallejo, Arturo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2019
Materias:
Computational Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6614823/
https://www.ncbi.nlm.nih.gov/pubmed/31114920
http://dx.doi.org/10.1093/nar/gkz463

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6614823/
https://www.ncbi.nlm.nih.gov/pubmed/31114920
http://dx.doi.org/10.1093/nar/gkz463

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