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Stability and sub-cellular localization of DNA polymerase β is regulated by interactions with NQO1 and XRCC1 in response to oxidative stress

Protein–protein interactions regulate many essential enzymatic processes in the cell. Somatic mutations outside of an enzyme active site can therefore impact cellular function by disruption of critical protein–protein interactions. In our investigation of the cellular impact of the T304I cancer muta...

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Detalles Bibliográficos
Autores principales:	Fang, Qingming, Andrews, Joel, Sharma, Nidhi, Wilk, Anna, Clark, Jennifer, Slyskova, Jana, Koczor, Christopher A, Lans, Hannes, Prakash, Aishwarya, Sobol, Robert W
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2019
Materias:	Genome Integrity, Repair and Replication
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6614843/ https://www.ncbi.nlm.nih.gov/pubmed/31287140 http://dx.doi.org/10.1093/nar/gkz293

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