Nano-scaled MTCA-KKV: for targeting thrombus, releasing pharmacophores, inhibiting thrombosis and dissolving blood clots in vivo

BACKGROUND: In vitro (1R,3S)-1-methyl-1,2,3,4-tetrahydro-β-carboline-3-carboxyl-Lys(Pro-Ala-Lys)-Arg-Gly-Asp-Val (MTCA-KKV) adheres activated platelets, targets P-selectin and GPIIb/IIIa. This led to the development of MTCA-KKV as thrombus targeting nano-medicine. METHODS: MTCA-KKV was characterized...

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Autores principales: Zhao, Shurui, Li, Ze, Huang, Fei, Wu, Jianhui, Gui, Lin, Zhang, Xiaoyi, Wang, Yaonan, Wang, Xiaozhen, Peng, Shiqi, Zhao, Ming
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove 2019
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6614858/
https://www.ncbi.nlm.nih.gov/pubmed/31308660
http://dx.doi.org/10.2147/IJN.S206294
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author Zhao, Shurui
Li, Ze
Huang, Fei
Wu, Jianhui
Gui, Lin
Zhang, Xiaoyi
Wang, Yaonan
Wang, Xiaozhen
Peng, Shiqi
Zhao, Ming
author_facet Zhao, Shurui
Li, Ze
Huang, Fei
Wu, Jianhui
Gui, Lin
Zhang, Xiaoyi
Wang, Yaonan
Wang, Xiaozhen
Peng, Shiqi
Zhao, Ming
author_sort Zhao, Shurui
collection PubMed
description BACKGROUND: In vitro (1R,3S)-1-methyl-1,2,3,4-tetrahydro-β-carboline-3-carboxyl-Lys(Pro-Ala-Lys)-Arg-Gly-Asp-Val (MTCA-KKV) adheres activated platelets, targets P-selectin and GPIIb/IIIa. This led to the development of MTCA-KKV as thrombus targeting nano-medicine. METHODS: MTCA-KKV was characterized by nano-feature, anti-thrombotic activity, thrombolytic activity, thrombus target and targeting release. RESULTS: In vivo 0.01 μmol/kg of MTCA-KKV formed nano-particles less than 100 nm in diameter, targeted thrombus, released anti-thrombotic and thrombolytic pharmacophores, prevented thrombosis and dissolved blood clots. CONCLUSION: Based on the profiles of targeting thrombus, targeting release, inhibiting thrombosis and dissolving blood clots MTCA-KKV is a promising nano-medicine.
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spelling pubmed-66148582019-07-15 Nano-scaled MTCA-KKV: for targeting thrombus, releasing pharmacophores, inhibiting thrombosis and dissolving blood clots in vivo Zhao, Shurui Li, Ze Huang, Fei Wu, Jianhui Gui, Lin Zhang, Xiaoyi Wang, Yaonan Wang, Xiaozhen Peng, Shiqi Zhao, Ming Int J Nanomedicine Original Research BACKGROUND: In vitro (1R,3S)-1-methyl-1,2,3,4-tetrahydro-β-carboline-3-carboxyl-Lys(Pro-Ala-Lys)-Arg-Gly-Asp-Val (MTCA-KKV) adheres activated platelets, targets P-selectin and GPIIb/IIIa. This led to the development of MTCA-KKV as thrombus targeting nano-medicine. METHODS: MTCA-KKV was characterized by nano-feature, anti-thrombotic activity, thrombolytic activity, thrombus target and targeting release. RESULTS: In vivo 0.01 μmol/kg of MTCA-KKV formed nano-particles less than 100 nm in diameter, targeted thrombus, released anti-thrombotic and thrombolytic pharmacophores, prevented thrombosis and dissolved blood clots. CONCLUSION: Based on the profiles of targeting thrombus, targeting release, inhibiting thrombosis and dissolving blood clots MTCA-KKV is a promising nano-medicine. Dove 2019-07-03 /pmc/articles/PMC6614858/ /pubmed/31308660 http://dx.doi.org/10.2147/IJN.S206294 Text en © 2019 Zhao et al. http://creativecommons.org/licenses/by-nc/3.0/ This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License (http://creativecommons.org/licenses/by-nc/3.0/). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms (https://www.dovepress.com/terms.php).
spellingShingle Original Research
Zhao, Shurui
Li, Ze
Huang, Fei
Wu, Jianhui
Gui, Lin
Zhang, Xiaoyi
Wang, Yaonan
Wang, Xiaozhen
Peng, Shiqi
Zhao, Ming
Nano-scaled MTCA-KKV: for targeting thrombus, releasing pharmacophores, inhibiting thrombosis and dissolving blood clots in vivo
title Nano-scaled MTCA-KKV: for targeting thrombus, releasing pharmacophores, inhibiting thrombosis and dissolving blood clots in vivo
title_full Nano-scaled MTCA-KKV: for targeting thrombus, releasing pharmacophores, inhibiting thrombosis and dissolving blood clots in vivo
title_fullStr Nano-scaled MTCA-KKV: for targeting thrombus, releasing pharmacophores, inhibiting thrombosis and dissolving blood clots in vivo
title_full_unstemmed Nano-scaled MTCA-KKV: for targeting thrombus, releasing pharmacophores, inhibiting thrombosis and dissolving blood clots in vivo
title_short Nano-scaled MTCA-KKV: for targeting thrombus, releasing pharmacophores, inhibiting thrombosis and dissolving blood clots in vivo
title_sort nano-scaled mtca-kkv: for targeting thrombus, releasing pharmacophores, inhibiting thrombosis and dissolving blood clots in vivo
topic Original Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6614858/
https://www.ncbi.nlm.nih.gov/pubmed/31308660
http://dx.doi.org/10.2147/IJN.S206294
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