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Quantifying Microsatellite Mutation Rates from Intestinal Stem Cell Dynamics in Msh2-Deficient Murine Epithelium

Microsatellite sequences have an enhanced susceptibility to mutation, and can act as sentinels indicating elevated mutation rates and increased risk of cancer. The probability of mutant fixation within the intestinal epithelium is dictated by a combination of stem cell dynamics and mutation rate. He...

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Detalles Bibliográficos
Autores principales:	Christopher, Joseph, Thorsen, Ann-Sofie, Abujudeh, Sam, Lourenço, Filipe C., Kemp, Richard, Potter, Paul K., Morrissey, Edward, Hazelwood, Lee, Winton, Douglas J.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Genetics Society of America 2019
Materias:	Investigations
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6614890/ https://www.ncbi.nlm.nih.gov/pubmed/31126976 http://dx.doi.org/10.1534/genetics.119.302268

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