Examining the Impact of Imputation Errors on Fine-Mapping Using DNA Methylation QTL as a Model Trait

Genetic variants disrupting DNA methylation at CpG dinucleotides (CpG-SNP) provide a set of known causal variants to serve as models to test fine-mapping methodology. We use 1716 CpG-SNPs to test three fine-mapping approaches (Bayesian imputation-based association mapping, Bayesian sparse linear mix...

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Detalles Bibliográficos
Autores principales: Chundru, V. Kartik, Marioni, Riccardo E., Prendergast, James G. D., Vallerga, Costanza L., Lin, Tian, Beveridge, Allan J., Gratten, Jacob, Hume, David A., Deary, Ian J., Wray, Naomi R., Visscher, Peter M., McRae, Allan F.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Genetics Society of America 2019
Materias:
Investigations
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6614908/
https://www.ncbi.nlm.nih.gov/pubmed/31040117
http://dx.doi.org/10.1534/genetics.118.301861

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6614908/
https://www.ncbi.nlm.nih.gov/pubmed/31040117
http://dx.doi.org/10.1534/genetics.118.301861

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