Cargando…
APEX1 Polymorphisms and Neuroblastoma Risk in Chinese Children: A Three-Center Case-Control Study
Neuroblastoma is a life-threatening extracranial solid tumor, preferentially occurring in children. However, its etiology remains unclear. APEX1 is a critical gene in the base excision repair (BER) system responsible for maintaining genome stability. Given the potential effects of APEX1 polymorphism...
Autores principales: | , , , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi
2019
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6614964/ https://www.ncbi.nlm.nih.gov/pubmed/31341530 http://dx.doi.org/10.1155/2019/5736175 |
_version_ | 1783433273895026688 |
---|---|
author | Liu, Jiabin Jia, Wei Hua, Rui-Xi Zhu, Jinhong Zhang, Jiao Yang, Tianyou Li, Peng Xia, Huimin He, Jing Cheng, Jiwen |
author_facet | Liu, Jiabin Jia, Wei Hua, Rui-Xi Zhu, Jinhong Zhang, Jiao Yang, Tianyou Li, Peng Xia, Huimin He, Jing Cheng, Jiwen |
author_sort | Liu, Jiabin |
collection | PubMed |
description | Neuroblastoma is a life-threatening extracranial solid tumor, preferentially occurring in children. However, its etiology remains unclear. APEX1 is a critical gene in the base excision repair (BER) system responsible for maintaining genome stability. Given the potential effects of APEX1 polymorphisms on the ability of the DNA damage repair, many studies have investigated the association between these variants and susceptibility to several types of cancer but not neuroblastoma. Here, we conducted a three-center case-control study to evaluate the association between APEX1 polymorphisms (rs1130409 T>G, rs1760944 T>G, and rs3136817 T>C) and neuroblastoma risk in Chinese children, consisting of 469 cases and 998 controls. Odds ratio (OR) and 95% confidence intervals (CIs) were calculated to evaluate the associations. No significant association with neuroblastoma risk was found for the studied APEX1 polymorphisms in the single locus or combination analysis. Interestingly, stratified analysis showed that rs1130409 GG genotype significantly reduced the risk of tumor in males. Furthermore, we found that carriers with 1-3 protective genotypes had a lower neuroblastoma risk in the children older than18 months and male, when compared to those without protective genotypes. In summary, our data indicate that APEX1 gene polymorphisms may have a weak effect on neuroblastoma susceptibility. These findings should be further validated by well-designed studies with larger sample size. |
format | Online Article Text |
id | pubmed-6614964 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | Hindawi |
record_format | MEDLINE/PubMed |
spelling | pubmed-66149642019-07-24 APEX1 Polymorphisms and Neuroblastoma Risk in Chinese Children: A Three-Center Case-Control Study Liu, Jiabin Jia, Wei Hua, Rui-Xi Zhu, Jinhong Zhang, Jiao Yang, Tianyou Li, Peng Xia, Huimin He, Jing Cheng, Jiwen Oxid Med Cell Longev Research Article Neuroblastoma is a life-threatening extracranial solid tumor, preferentially occurring in children. However, its etiology remains unclear. APEX1 is a critical gene in the base excision repair (BER) system responsible for maintaining genome stability. Given the potential effects of APEX1 polymorphisms on the ability of the DNA damage repair, many studies have investigated the association between these variants and susceptibility to several types of cancer but not neuroblastoma. Here, we conducted a three-center case-control study to evaluate the association between APEX1 polymorphisms (rs1130409 T>G, rs1760944 T>G, and rs3136817 T>C) and neuroblastoma risk in Chinese children, consisting of 469 cases and 998 controls. Odds ratio (OR) and 95% confidence intervals (CIs) were calculated to evaluate the associations. No significant association with neuroblastoma risk was found for the studied APEX1 polymorphisms in the single locus or combination analysis. Interestingly, stratified analysis showed that rs1130409 GG genotype significantly reduced the risk of tumor in males. Furthermore, we found that carriers with 1-3 protective genotypes had a lower neuroblastoma risk in the children older than18 months and male, when compared to those without protective genotypes. In summary, our data indicate that APEX1 gene polymorphisms may have a weak effect on neuroblastoma susceptibility. These findings should be further validated by well-designed studies with larger sample size. Hindawi 2019-06-25 /pmc/articles/PMC6614964/ /pubmed/31341530 http://dx.doi.org/10.1155/2019/5736175 Text en Copyright © 2019 Jiabin Liu et al. http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Research Article Liu, Jiabin Jia, Wei Hua, Rui-Xi Zhu, Jinhong Zhang, Jiao Yang, Tianyou Li, Peng Xia, Huimin He, Jing Cheng, Jiwen APEX1 Polymorphisms and Neuroblastoma Risk in Chinese Children: A Three-Center Case-Control Study |
title |
APEX1 Polymorphisms and Neuroblastoma Risk in Chinese Children: A Three-Center Case-Control Study |
title_full |
APEX1 Polymorphisms and Neuroblastoma Risk in Chinese Children: A Three-Center Case-Control Study |
title_fullStr |
APEX1 Polymorphisms and Neuroblastoma Risk in Chinese Children: A Three-Center Case-Control Study |
title_full_unstemmed |
APEX1 Polymorphisms and Neuroblastoma Risk in Chinese Children: A Three-Center Case-Control Study |
title_short |
APEX1 Polymorphisms and Neuroblastoma Risk in Chinese Children: A Three-Center Case-Control Study |
title_sort | apex1 polymorphisms and neuroblastoma risk in chinese children: a three-center case-control study |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6614964/ https://www.ncbi.nlm.nih.gov/pubmed/31341530 http://dx.doi.org/10.1155/2019/5736175 |
work_keys_str_mv | AT liujiabin apex1polymorphismsandneuroblastomariskinchinesechildrenathreecentercasecontrolstudy AT jiawei apex1polymorphismsandneuroblastomariskinchinesechildrenathreecentercasecontrolstudy AT huaruixi apex1polymorphismsandneuroblastomariskinchinesechildrenathreecentercasecontrolstudy AT zhujinhong apex1polymorphismsandneuroblastomariskinchinesechildrenathreecentercasecontrolstudy AT zhangjiao apex1polymorphismsandneuroblastomariskinchinesechildrenathreecentercasecontrolstudy AT yangtianyou apex1polymorphismsandneuroblastomariskinchinesechildrenathreecentercasecontrolstudy AT lipeng apex1polymorphismsandneuroblastomariskinchinesechildrenathreecentercasecontrolstudy AT xiahuimin apex1polymorphismsandneuroblastomariskinchinesechildrenathreecentercasecontrolstudy AT hejing apex1polymorphismsandneuroblastomariskinchinesechildrenathreecentercasecontrolstudy AT chengjiwen apex1polymorphismsandneuroblastomariskinchinesechildrenathreecentercasecontrolstudy |