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Effect of Social Factors and the Natural Environment on the Etiology and Pathogenesis of Diabetes Mellitus

Type 2 diabetes mellitus (T2DM) is currently a public health problem worldwide and a threat to human health and social development. The incidence rate of the disease is steadily increasing. Various genetic and environmental factors have been established as influencing the pathogenesis of this diseas...

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Autores principales: Dong, Guangtong, Qu, Lianlian, Gong, Xuefeng, Pang, Bing, Yan, Weitian, Wei, Junping
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6614969/
https://www.ncbi.nlm.nih.gov/pubmed/31341475
http://dx.doi.org/10.1155/2019/8749291
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author Dong, Guangtong
Qu, Lianlian
Gong, Xuefeng
Pang, Bing
Yan, Weitian
Wei, Junping
author_facet Dong, Guangtong
Qu, Lianlian
Gong, Xuefeng
Pang, Bing
Yan, Weitian
Wei, Junping
author_sort Dong, Guangtong
collection PubMed
description Type 2 diabetes mellitus (T2DM) is currently a public health problem worldwide and a threat to human health and social development. The incidence rate of the disease is steadily increasing. Various genetic and environmental factors have been established as influencing the pathogenesis of this disease. However, the influence of social factors and the natural environment on DM incidence should also be considered. Low-grade inflammation could represent a central point of connection integrating all these potential triggers, being partly responsible for the development of insulin resistance. This paper aims to elaborate on the impact of the natural environment and social factors on DM development, with a special focus on six aspects of the pathogenesis of DM: pollution, radiation, psychology, drink, sleep, and exercise. We identified a two-way relationship between T2DM and social and natural environments. Changes in these environments may lead to low-grade inflammation, which in turn induces or aggravates T2DM and vice versa. Poor lifestyle may lead to increased insulin resistance and promote DM development. Improvements in blood glucose control can be achieved through nonenvironmental and behavioral interventions.
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spelling pubmed-66149692019-07-24 Effect of Social Factors and the Natural Environment on the Etiology and Pathogenesis of Diabetes Mellitus Dong, Guangtong Qu, Lianlian Gong, Xuefeng Pang, Bing Yan, Weitian Wei, Junping Int J Endocrinol Review Article Type 2 diabetes mellitus (T2DM) is currently a public health problem worldwide and a threat to human health and social development. The incidence rate of the disease is steadily increasing. Various genetic and environmental factors have been established as influencing the pathogenesis of this disease. However, the influence of social factors and the natural environment on DM incidence should also be considered. Low-grade inflammation could represent a central point of connection integrating all these potential triggers, being partly responsible for the development of insulin resistance. This paper aims to elaborate on the impact of the natural environment and social factors on DM development, with a special focus on six aspects of the pathogenesis of DM: pollution, radiation, psychology, drink, sleep, and exercise. We identified a two-way relationship between T2DM and social and natural environments. Changes in these environments may lead to low-grade inflammation, which in turn induces or aggravates T2DM and vice versa. Poor lifestyle may lead to increased insulin resistance and promote DM development. Improvements in blood glucose control can be achieved through nonenvironmental and behavioral interventions. Hindawi 2019-06-25 /pmc/articles/PMC6614969/ /pubmed/31341475 http://dx.doi.org/10.1155/2019/8749291 Text en Copyright © 2019 Guangtong Dong et al. https://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Dong, Guangtong
Qu, Lianlian
Gong, Xuefeng
Pang, Bing
Yan, Weitian
Wei, Junping
Effect of Social Factors and the Natural Environment on the Etiology and Pathogenesis of Diabetes Mellitus
title Effect of Social Factors and the Natural Environment on the Etiology and Pathogenesis of Diabetes Mellitus
title_full Effect of Social Factors and the Natural Environment on the Etiology and Pathogenesis of Diabetes Mellitus
title_fullStr Effect of Social Factors and the Natural Environment on the Etiology and Pathogenesis of Diabetes Mellitus
title_full_unstemmed Effect of Social Factors and the Natural Environment on the Etiology and Pathogenesis of Diabetes Mellitus
title_short Effect of Social Factors and the Natural Environment on the Etiology and Pathogenesis of Diabetes Mellitus
title_sort effect of social factors and the natural environment on the etiology and pathogenesis of diabetes mellitus
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6614969/
https://www.ncbi.nlm.nih.gov/pubmed/31341475
http://dx.doi.org/10.1155/2019/8749291
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