Completely resolved advanced biliary tract cancer after treatment by pembrolizumab: a report of two cases

Biliary tract cancers (BTC) represent an aggressive disease with a dismal prognosis. Gemcitabine in combination with cisplatin is the standard first-line palliative treatment for advanced BTC. There is no established treatment following progression on gemcitabine-cisplatin. In this article, we prese...

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Autores principales: Alshari, Osama M, Dawaymeh, Tamara A, Tashtush, Nour A, Aleshawi, Abdelwahab J, Al Manasra, Abdel Rahman A, Obeidat, Khaled A
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove 2019
Materias:
Case Series
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6615017/
https://www.ncbi.nlm.nih.gov/pubmed/31308699
http://dx.doi.org/10.2147/OTT.S197559
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author Alshari, Osama M
Dawaymeh, Tamara A
Tashtush, Nour A
Aleshawi, Abdelwahab J
Al Manasra, Abdel Rahman A
Obeidat, Khaled A
author_facet Alshari, Osama M
Dawaymeh, Tamara A
Tashtush, Nour A
Aleshawi, Abdelwahab J
Al Manasra, Abdel Rahman A
Obeidat, Khaled A
author_sort Alshari, Osama M
collection PubMed
description Biliary tract cancers (BTC) represent an aggressive disease with a dismal prognosis. Gemcitabine in combination with cisplatin is the standard first-line palliative treatment for advanced BTC. There is no established treatment following progression on gemcitabine-cisplatin. In this article, we present two cases for individuals with advanced BTC who were treated with pembrolizumab and the tumors have completely resolved.
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spelling pubmed-66150172019-07-15 Completely resolved advanced biliary tract cancer after treatment by pembrolizumab: a report of two cases Alshari, Osama M Dawaymeh, Tamara A Tashtush, Nour A Aleshawi, Abdelwahab J Al Manasra, Abdel Rahman A Obeidat, Khaled A Onco Targets Ther Case Series Biliary tract cancers (BTC) represent an aggressive disease with a dismal prognosis. Gemcitabine in combination with cisplatin is the standard first-line palliative treatment for advanced BTC. There is no established treatment following progression on gemcitabine-cisplatin. In this article, we present two cases for individuals with advanced BTC who were treated with pembrolizumab and the tumors have completely resolved. Dove 2019-07-04 /pmc/articles/PMC6615017/ /pubmed/31308699 http://dx.doi.org/10.2147/OTT.S197559 Text en © 2019 Alshari et al. http://creativecommons.org/licenses/by-nc/3.0/ This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License (http://creativecommons.org/licenses/by-nc/3.0/). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms (https://www.dovepress.com/terms.php).
spellingShingle Case Series
Alshari, Osama M
Dawaymeh, Tamara A
Tashtush, Nour A
Aleshawi, Abdelwahab J
Al Manasra, Abdel Rahman A
Obeidat, Khaled A
Completely resolved advanced biliary tract cancer after treatment by pembrolizumab: a report of two cases
title Completely resolved advanced biliary tract cancer after treatment by pembrolizumab: a report of two cases
title_full Completely resolved advanced biliary tract cancer after treatment by pembrolizumab: a report of two cases
title_fullStr Completely resolved advanced biliary tract cancer after treatment by pembrolizumab: a report of two cases
title_full_unstemmed Completely resolved advanced biliary tract cancer after treatment by pembrolizumab: a report of two cases
title_short Completely resolved advanced biliary tract cancer after treatment by pembrolizumab: a report of two cases
title_sort completely resolved advanced biliary tract cancer after treatment by pembrolizumab: a report of two cases
topic Case Series
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6615017/
https://www.ncbi.nlm.nih.gov/pubmed/31308699
http://dx.doi.org/10.2147/OTT.S197559
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