Cargando…

Intranasal mesenchymal stem cell secretome administration markedly inhibits alcohol and nicotine self-administration and blocks relapse-intake: mechanism and translational options

BACKGROUND: Chronic consumption of most drugs of abuse leads to brain oxidative stress and neuroinflammation, which inhibit the glutamate transporter GLT-1, proposed to perpetuate drug intake. The present study aimed at inhibiting chronic ethanol and nicotine self-administration and relapse by the n...

Descripción completa

Detalles Bibliográficos
Autores principales:	Quintanilla, María Elena, Ezquer, Fernando, Morales, Paola, Santapau, Daniela, Berríos-Cárcamo, Pablo, Ezquer, Marcelo, Herrera-Marschitz, Mario, Israel, Yedy
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2019
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6615104/ https://www.ncbi.nlm.nih.gov/pubmed/31286996 http://dx.doi.org/10.1186/s13287-019-1304-z

Ejemplares similares

Effect of human mesenchymal stem cell secretome administration on morphine self-administration and relapse in two animal models of opioid dependence
por: Quintanilla, María Elena, et al.
Publicado: (2022)

Administration of N-acetylcysteine Plus Acetylsalicylic Acid Markedly Inhibits Nicotine Reinstatement Following Chronic Oral Nicotine Intake in Female Rats
por: Quintanilla, María Elena, et al.
Publicado: (2021)

Intravenous administration of anti-inflammatory mesenchymal stem cell spheroids reduces chronic alcohol intake and abolishes binge-drinking
por: Ezquer, Fernando, et al.
Publicado: (2018)

Oxidative Stress and Neuroinflammation as a Pivot in Drug Abuse. A Focus on the Therapeutic Potential of Antioxidant and Anti-Inflammatory Agents and Biomolecules
por: Berríos-Cárcamo, Pablo, et al.
Publicado: (2020)

N-Acetylcysteine and Acetylsalicylic Acid Inhibit Alcohol Consumption by Different Mechanisms: Combined Protection
por: Quintanilla, María Elena, et al.
Publicado: (2020)

A Novel Morphine Drinking Model of Opioid Dependence in Rats
por: Berríos-Cárcamo, Pablo, et al.
Publicado: (2022)

Intranasal Administration of Mesenchymal Stem Cell Secretome Reduces Hippocampal Oxidative Stress, Neuroinflammation and Cell Death, Improving the Behavioral Outcome Following Perinatal Asphyxia
por: Farfán, Nancy, et al.
Publicado: (2020)

Acquisition, Maintenance and Relapse-Like Alcohol Drinking: Lessons from the UChB Rat Line
por: Israel, Yedy, et al.
Publicado: (2017)

Administration of Secretome Derived from Human Mesenchymal Stem Cells Induces Hepatoprotective Effects in Models of Idiosyncratic Drug-Induced Liver Injury Caused by Amiodarone or Tamoxifen
por: Huang, Ya-Lin, et al.
Publicado: (2023)

Administration of multipotent mesenchymal stromal cells restores liver regeneration and improves liver function in obese mice with hepatic steatosis after partial hepatectomy
por: Ezquer, Fernando, et al.
Publicado: (2017)

Intravitreal administration of multipotent mesenchymal stromal cells triggers a cytoprotective microenvironment in the retina of diabetic mice
por: Ezquer, Marcelo, et al.
Publicado: (2016)

Sustained Energy Deficit Following Perinatal Asphyxia: A Shift towards the Fructose-2,6-bisphosphatase (TIGAR)-Dependent Pentose Phosphate Pathway and Postnatal Development
por: Lespay-Rebolledo, Carolyne, et al.
Publicado: (2021)

Intranasal administration of induced pluripotent stem cell-derived cortical neural stem cell-secretome as a treatment option for Alzheimer’s disease
por: Mo, Hyunkyung, et al.
Publicado: (2023)

Gene specific modifications unravel ethanol and acetaldehyde actions
por: Israel, Yedy, et al.
Publicado: (2013)

High Fat Diet-Induced Skeletal Muscle Wasting Is Decreased by Mesenchymal Stem Cells Administration: Implications on Oxidative Stress, Ubiquitin Proteasome Pathway Activation, and Myonuclear Apoptosis
por: Abrigo, Johanna, et al.
Publicado: (2016)

Racemic Salsolinol and its Enantiomers Act as Agonists of the μ-Opioid Receptor by Activating the Gi Protein-Adenylate Cyclase Pathway
por: Berríos-Cárcamo, Pablo, et al.
Publicado: (2017)

Human adipose-derived mesenchymal stem cell-conditioned medium ameliorates polyneuropathy and foot ulceration in diabetic BKS db/db mice
por: De Gregorio, Cristian, et al.
Publicado: (2020)

Intranasal administration of acetylcholinesterase inhibitors
por: Costantino, Henry R, et al.
Publicado: (2008)

Improving Cell Recovery: Freezing and Thawing Optimization of Induced Pluripotent Stem Cells
por: Uhrig, Markus, et al.
Publicado: (2022)

New Perspectives to Improve Mesenchymal Stem Cell Therapies for Drug-Induced Liver Injury
por: Ezquer, Fernando, et al.
Publicado: (2022)

Postprandial Administration of Intranasal Insulin Intensifies Satiety and Reduces Intake of Palatable Snacks in Women
por: Hallschmid, Manfred, et al.
Publicado: (2012)

The Antidiabetic Effect of MSCs Is Not Impaired by Insulin Prophylaxis and Is Not Improved by a Second Dose of Cells
por: Ezquer, Fernando, et al.
Publicado: (2011)

Neonatal Mesenchymal Stem Cell Treatment Improves Myelination Impaired by Global Perinatal Asphyxia in Rats
por: Tapia-Bustos, Andrea, et al.
Publicado: (2021)

Intranasal Administration of Mammary Tumour Milk Factor
por: Begg, A. M.
Publicado: (1949)

Design and Efficacy of Nanogels Formulations for Intranasal Administration
por: Aderibigbe, Blessing A., et al.
Publicado: (2018)

Inadequate quality of administration of intranasal corticosteroid sprays
por: Rollema, Corine, et al.
Publicado: (2019)

Pharmacokinetics of Nanosomal Form of Levodopa in Intranasal Administration
por: Nedorubov, Andrey Anatolievich, et al.
Publicado: (2019)

Intranasal Administration for Pain: Oxytocin and Other Polypeptides
por: Bharadwaj, Vimala N., et al.
Publicado: (2021)

Characterization of diabetic neuropathy progression in a mouse model of type 2 diabetes mellitus
por: De Gregorio, Cristian, et al.
Publicado: (2018)

Oral Administration of Oxytocin, Like Intranasal Administration, Decreases Top-Down Social Attention
por: Zhuang, Qian, et al.
Publicado: (2022)

Worsening psychosis associated with administrations of buspirone and concerns for intranasal administration: A case report
por: Apeldoorn, Samuel, et al.
Publicado: (2023)

Two complementary strategies to improve cell engraftment in mesenchymal stem cell-based therapy: Increasing transplanted cell resistance and increasing tissue receptivity
por: Ezquer, Fernando E., et al.
Publicado: (2016)

Targeting glioblastoma via intranasal administration of Ff bacteriophages
por: Dor-On, Eyal, et al.
Publicado: (2015)

Efficacy of intranasal administration of artesunate in experimental cerebral malaria
por: Marijon, Anne, et al.
Publicado: (2014)

Anxiolytic Action of Taurine via Intranasal Administration in Mice
por: Jung, Jung Hwa, et al.
Publicado: (2019)

Intranasal administration of dantrolene increased brain concentration and duration
por: Wang, Jintao, et al.
Publicado: (2020)

Essential Oil-Loaded NLC for Potential Intranasal Administration
por: Bonaccorso, Angela, et al.
Publicado: (2021)

Evaluation of the techniques and steps of intranasal corticosteroid sprays administration
por: Rattanawong, Supachet, et al.
Publicado: (2022)

Application of Intranasal Administration in the Delivery of Antidepressant Active Ingredients
por: Jin, Zhiyu, et al.
Publicado: (2022)

Pharmacokinetics and tolerability of intranasal or intravenous administration of nalbuphine in infants
por: Pfiffner, Miriam, et al.
Publicado: (2023)

Cannot write session to /tmp/vufind_sessions/sess_5o3agusvifl5s6qosbcn67ueub