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Deletion of Tet proteins results in quantitative disparities during ESC differentiation partially attributable to alterations in gene expression
BACKGROUND: The Tet protein family (Tet1, Tet2, and Tet3) regulate DNA methylation through conversion of 5-methylcytosine to 5-hydroxymethylcytosine which can ultimately result in DNA demethylation and play a critical role during early mammalian development and pluripotency. While multiple groups ha...
| Autores principales: | , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
BioMed Central
2019
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6615237/ https://www.ncbi.nlm.nih.gov/pubmed/31286885 http://dx.doi.org/10.1186/s12861-019-0196-6 |