Cargando…

The binding affinity of PTPN13’s tandem PDZ2/3 domain is allosterically modulated

BACKGROUND: Protein tyrosine phosphatase PTPN13, also known as PTP-BL in mice, is a large multi-domain non-transmembrane scaffolding protein with a molecular mass of 270 kDa. It is involved in the regulation of several cellular processes such as cytokinesis and actin-cytoskeletal rearrangement. The...

Descripción completa

Detalles Bibliográficos
Autores principales:	Dicks, Markus, Kock, Gerd, Kohl, Bastian, Zhong, Xueyin, Pütz, Stefanie, Heumann, Rolf, Erdmann, Kai S., Stoll, Raphael
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2019
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6615252/ https://www.ncbi.nlm.nih.gov/pubmed/31286859 http://dx.doi.org/10.1186/s12860-019-0203-6

Ejemplares similares

Allosterism in the PDZ Family
por: Stevens, Amy O., et al.
Publicado: (2022)

Seeking allosteric networks in PDZ domains
por: Gautier, Candice, et al.
Publicado: (2018)

Allosteric Activation of GDP-Bound Ras Isoforms by Bisphenol Derivative Plasticisers
por: Schöpel, Miriam, et al.
Publicado: (2018)

Change in Allosteric Network Affects Binding Affinities of PDZ Domains: Analysis through Perturbation Response Scanning
por: Gerek, Z. Nevin, et al.
Publicado: (2011)

Regulation of the Human Phosphatase PTPN4 by the inter-domain linker connecting the PDZ and the phosphatase domains
por: Caillet-Saguy, Célia, et al.
Publicado: (2017)

Phosphorylation orchestrates the structural ensemble of the intrinsically disordered protein HMGA1a and modulates its DNA binding to the NFκB promoter
por: Kohl, Bastian, et al.
Publicado: (2019)

The FERM and PDZ Domain-Containing Protein Tyrosine Phosphatases, PTPN4 and PTPN3, Are Both Dispensable for T Cell Receptor Signal Transduction
por: Bauler, Timothy J., et al.
Publicado: (2008)

Role of Terahertz (THz) Fluctuations in the Allosteric Properties of the PDZ Domains
por: Conti Nibali, Valeria, et al.
Publicado: (2017)

Allosteric Signaling in PDZ Energetic Networks: Embedding Error Analysis
por: Cowan, Benjamin S., et al.
Publicado: (2023)

Structural and functional characterization of the PDZ domain of the human phosphatase PTPN3 and its interaction with the human papillomavirus E6 oncoprotein
por: Genera, Mariano, et al.
Publicado: (2019)

Cysteine modifiers suggest an allosteric inhibitory site on the CAL PDZ domain
por: Zhao, Yu, et al.
Publicado: (2018)

Correction: Cysteine modification reveals an allosteric inhibitory site on the CAL PDZ domain
por: Zhao, Yu, et al.
Publicado: (2018)

An unexpected INAD PDZ tandem-mediated plcβ binding in Drosophila photo receptors
por: Ye, Fei, et al.
Publicado: (2018)

Improved affinity at the cost of decreased specificity: a recurring theme in PDZ-peptide interactions
por: Karlsson, O. Andreas, et al.
Publicado: (2016)

Interactions of the protein tyrosine phosphatase PTPN3 with viral and cellular partners through its PDZ domain: insights into structural determinants and phosphatase activity
por: Genera, Mariano, et al.
Publicado: (2023)

Ras and Rheb Signaling in Survival and Cell Death
por: Ehrkamp, Anja, et al.
Publicado: (2013)

Dual Role of the PTPN13 Tyrosine Phosphatase in Cancer
por: Mcheik, Soha, et al.
Publicado: (2020)

Cluster based prediction of PDZ-peptide interactions
por: Kundu, Kousik, et al.
Publicado: (2014)

Affinity Enhancement by Ligand Clustering Effect Inspired by Peptide Dendrimers−Shank PDZ Proteins Interactions
por: Liu, Jiahui, et al.
Publicado: (2016)

An In Silico Analysis of the Binding Modes and Binding Affinities of Small Molecule Modulators of PDZ-Peptide Interactions
por: Tiwari, Garima, et al.
Publicado: (2013)

Ras Homolog Enriched in Brain (Rheb) Enhances Apoptotic Signaling
por: Karassek, Sascha, et al.
Publicado: (2010)

Functional Short Tandem Repeat Polymorphism of PTPN11 and Susceptibility to Hepatocellular Carcinoma in Chinese Populations
por: Zhao, Xiankun, et al.
Publicado: (2014)

A high‐affinity, bivalent PDZ domain inhibitor complexes PICK1 to alleviate neuropathic pain
por: Christensen, Nikolaj R, et al.
Publicado: (2020)

Identifying weak interdomain interactions that stabilize the supertertiary structure of the N-terminal tandem PDZ domains of PSD-95
por: Yanez Orozco, Inna S., et al.
Publicado: (2018)

Coevolution and smFRET Enhances Conformation Sampling and FRET Experimental Design in Tandem PDZ1–2 Proteins
por: Krishnamohan, Aishwarya, et al.
Publicado: (2023)

PDZ domain-mediated dimerization and homeodomain-directed specificity are required for high-affinity DNA binding by SATB1
por: Purbey, Prabhat Kumar, et al.
Publicado: (2008)

PDZ Domains and Viral Infection: Versatile Potentials of HPV-PDZ Interactions in relation to Malignancy
por: Nagasaka, Kazunori, et al.
Publicado: (2013)

The mechanism of a high-affinity allosteric inhibitor of the serotonin transporter
por: Plenge, Per, et al.
Publicado: (2020)

rs2476601 in PTPN22 gene in rheumatoid arthritis and periodontitis—a possible interface?
por: Schulz, Susanne, et al.
Publicado: (2020)

PTPN13 induces cell junction stabilization and inhibits mammary tumor invasiveness
por: Hamyeh, Mohamed, et al.
Publicado: (2020)

The Chlamydia trachomatis Protease CPAF Contains a Cryptic PDZ-Like Domain with Similarity to Human Cell Polarity and Tight Junction PDZ-Containing Proteins
por: Maksimchuk, Kenneth R., et al.
Publicado: (2016)

Experiment-guided molecular simulations define a heterogeneous structural ensemble for the PTPN11 tandem SH2 domains
por: Marasco, Michelangelo, et al.
Publicado: (2023)

Phosphorylation of Connexin36 near the C-terminus switches binding affinities for PDZ-domain and 14–3–3 proteins in vitro
por: Tetenborg, Stephan, et al.
Publicado: (2020)

Association between the PTPN22 +1858 C/T polymorphism and psoriatic arthritis
por: Juneblad, Kristina, et al.
Publicado: (2011)

Interaction prediction and classification of PDZ domains
por: Kalyoncu, Sibel, et al.
Publicado: (2010)

The Conformational Plasticity Vista of PDZ Domains
por: Murciano-Calles, Javier
Publicado: (2020)

Concomitant deletion of Ptpn6 and Ptpn11 in T cells fails to improve anticancer responses
por: Ventura, Pedro M O, et al.
Publicado: (2022)

Genome-Wide Analysis of PDZ Domain Binding Reveals Inherent Functional Overlap within the PDZ Interaction Network
por: te Velthuis, Aartjan J. W., et al.
Publicado: (2011)

Discovery of High-Affinity Noncovalent Allosteric KRAS Inhibitors That Disrupt Effector Binding
por: McCarthy, Michael J., et al.
Publicado: (2019)

Identification of Protein Interacting Partners Using Tandem Affinity Purification
por: Bailey, Dalan, et al.
Publicado: (2012)

Cannot write session to /tmp/vufind_sessions/sess_sk11dcfgrr9u4tfc1i836eu0gi