Nuclear factor of activated T-cells, NFATC1, governs FLT3(ITD)-driven hematopoietic stem cell transformation and a poor prognosis in AML

BACKGROUND: Acute myeloid leukemia (AML) patients with a high allelic burden of an internal tandem duplication (ITD)-mutated FMS-like Tyrosine Kinase-3 (FLT3) have a dismal outcome. FLT3(ITD) triggers the proliferation of the quiescent hematopoietic stem cell (HSC) pool but fails to directly transfo...

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Detalles Bibliográficos
Autores principales: Solovey, Maria, Wang, Ying, Michel, Christian, Metzeler, Klaus H., Herold, Tobias, Göthert, Joachim R., Ellenrieder, Volker, Hessmann, Elisabeth, Gattenlöhner, Stefan, Neubauer, Andreas, Pavlinic, Dinko, Benes, Vladimir, Rupp, Oliver, Burchert, Andreas
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2019
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6615262/
https://www.ncbi.nlm.nih.gov/pubmed/31286998
http://dx.doi.org/10.1186/s13045-019-0765-y

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6615262/
https://www.ncbi.nlm.nih.gov/pubmed/31286998
http://dx.doi.org/10.1186/s13045-019-0765-y

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