Cargando…
Disease activity and damage in juvenile idiopathic arthritis: methotrexate era versus biologic era
OBJECTIVE: To compare the long-term disease state, in terms of activity and damage, of children with juvenile idiopathic arthritis (JIA) who had their disease onset in methotrexate (MTX) or biologic eras. METHODS: Patients were included in MTX or biologic era cohort depending on whether their diseas...
Autores principales: | , , , , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2019
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6615271/ https://www.ncbi.nlm.nih.gov/pubmed/31287015 http://dx.doi.org/10.1186/s13075-019-1950-7 |
_version_ | 1783433336757157888 |
---|---|
author | Giancane, Gabriella Muratore, Valentina Marzetti, Valentina Quilis, Neus Benavente, Belen Serrano Bagnasco, Francesca Alongi, Alessandra Civino, Adele Quartulli, Lorenzo Consolaro, Alessandro Ravelli, Angelo |
author_facet | Giancane, Gabriella Muratore, Valentina Marzetti, Valentina Quilis, Neus Benavente, Belen Serrano Bagnasco, Francesca Alongi, Alessandra Civino, Adele Quartulli, Lorenzo Consolaro, Alessandro Ravelli, Angelo |
author_sort | Giancane, Gabriella |
collection | PubMed |
description | OBJECTIVE: To compare the long-term disease state, in terms of activity and damage, of children with juvenile idiopathic arthritis (JIA) who had their disease onset in methotrexate (MTX) or biologic eras. METHODS: Patients were included in MTX or biologic era cohort depending on whether their disease presentation occurred before or after January 2000. All patients had disease duration ≥ 5 years and underwent a prospective cross-sectional assessment, which included measurement of disease activity and damage. Inactive disease (ID) and low disease activity (LDA) states were defined according to Wallace, JADAS10, and cJADAS10 criteria. Articular and extraarticular damage was assessed with the Juvenile Arthritis Damage Index (JADI). RESULTS: MTX and biologic era cohorts included 239 and 269 patients, respectively. Patients were divided in the “functional phenotypes” of oligoarthritis and polyarthritis. At cross-sectional visit, patients in the biologic era cohort with either oligoarthritis or polyarthritis had consistently higher frequencies of ID and LDA by all criteria. The measurement of disease damage at cross-sectional visit revealed that the frequency of impairment of > 1 JADI-Articular items was higher in MTX than in biologic era cohort (17.6% versus 11% in oligoarthritis and 52.6% versus 21.8% in polyarthritis). Likewise, frequency of involvement of > 1 JADI-Extraarticular items was higher in the MTX than in the biologic era cohort (26.5% versus 16.2% in oligoarthritis and 31.4% versus 13.5% in polyarthritis). CONCLUSION: Our study provides evidence of the remarkable outcome improvement obtained with the recent therapeutic advance in JIA. |
format | Online Article Text |
id | pubmed-6615271 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-66152712019-07-18 Disease activity and damage in juvenile idiopathic arthritis: methotrexate era versus biologic era Giancane, Gabriella Muratore, Valentina Marzetti, Valentina Quilis, Neus Benavente, Belen Serrano Bagnasco, Francesca Alongi, Alessandra Civino, Adele Quartulli, Lorenzo Consolaro, Alessandro Ravelli, Angelo Arthritis Res Ther Research Article OBJECTIVE: To compare the long-term disease state, in terms of activity and damage, of children with juvenile idiopathic arthritis (JIA) who had their disease onset in methotrexate (MTX) or biologic eras. METHODS: Patients were included in MTX or biologic era cohort depending on whether their disease presentation occurred before or after January 2000. All patients had disease duration ≥ 5 years and underwent a prospective cross-sectional assessment, which included measurement of disease activity and damage. Inactive disease (ID) and low disease activity (LDA) states were defined according to Wallace, JADAS10, and cJADAS10 criteria. Articular and extraarticular damage was assessed with the Juvenile Arthritis Damage Index (JADI). RESULTS: MTX and biologic era cohorts included 239 and 269 patients, respectively. Patients were divided in the “functional phenotypes” of oligoarthritis and polyarthritis. At cross-sectional visit, patients in the biologic era cohort with either oligoarthritis or polyarthritis had consistently higher frequencies of ID and LDA by all criteria. The measurement of disease damage at cross-sectional visit revealed that the frequency of impairment of > 1 JADI-Articular items was higher in MTX than in biologic era cohort (17.6% versus 11% in oligoarthritis and 52.6% versus 21.8% in polyarthritis). Likewise, frequency of involvement of > 1 JADI-Extraarticular items was higher in the MTX than in the biologic era cohort (26.5% versus 16.2% in oligoarthritis and 31.4% versus 13.5% in polyarthritis). CONCLUSION: Our study provides evidence of the remarkable outcome improvement obtained with the recent therapeutic advance in JIA. BioMed Central 2019-07-08 2019 /pmc/articles/PMC6615271/ /pubmed/31287015 http://dx.doi.org/10.1186/s13075-019-1950-7 Text en © The Author(s). 2019 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated. |
spellingShingle | Research Article Giancane, Gabriella Muratore, Valentina Marzetti, Valentina Quilis, Neus Benavente, Belen Serrano Bagnasco, Francesca Alongi, Alessandra Civino, Adele Quartulli, Lorenzo Consolaro, Alessandro Ravelli, Angelo Disease activity and damage in juvenile idiopathic arthritis: methotrexate era versus biologic era |
title | Disease activity and damage in juvenile idiopathic arthritis: methotrexate era versus biologic era |
title_full | Disease activity and damage in juvenile idiopathic arthritis: methotrexate era versus biologic era |
title_fullStr | Disease activity and damage in juvenile idiopathic arthritis: methotrexate era versus biologic era |
title_full_unstemmed | Disease activity and damage in juvenile idiopathic arthritis: methotrexate era versus biologic era |
title_short | Disease activity and damage in juvenile idiopathic arthritis: methotrexate era versus biologic era |
title_sort | disease activity and damage in juvenile idiopathic arthritis: methotrexate era versus biologic era |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6615271/ https://www.ncbi.nlm.nih.gov/pubmed/31287015 http://dx.doi.org/10.1186/s13075-019-1950-7 |
work_keys_str_mv | AT giancanegabriella diseaseactivityanddamageinjuvenileidiopathicarthritismethotrexateeraversusbiologicera AT muratorevalentina diseaseactivityanddamageinjuvenileidiopathicarthritismethotrexateeraversusbiologicera AT marzettivalentina diseaseactivityanddamageinjuvenileidiopathicarthritismethotrexateeraversusbiologicera AT quilisneus diseaseactivityanddamageinjuvenileidiopathicarthritismethotrexateeraversusbiologicera AT benaventebelenserrano diseaseactivityanddamageinjuvenileidiopathicarthritismethotrexateeraversusbiologicera AT bagnascofrancesca diseaseactivityanddamageinjuvenileidiopathicarthritismethotrexateeraversusbiologicera AT alongialessandra diseaseactivityanddamageinjuvenileidiopathicarthritismethotrexateeraversusbiologicera AT civinoadele diseaseactivityanddamageinjuvenileidiopathicarthritismethotrexateeraversusbiologicera AT quartullilorenzo diseaseactivityanddamageinjuvenileidiopathicarthritismethotrexateeraversusbiologicera AT consolaroalessandro diseaseactivityanddamageinjuvenileidiopathicarthritismethotrexateeraversusbiologicera AT ravelliangelo diseaseactivityanddamageinjuvenileidiopathicarthritismethotrexateeraversusbiologicera |