Correlation between frataxin expression and contractility revealed by in vitro Friedreich’s ataxia cardiac tissue models engineered from human pluripotent stem cells

BACKGROUND: Friedreich’s ataxia (FRDA) is an autosomal recessive disease caused by a non-coding mutation in the first intron of the frataxin (FXN) gene that suppresses its expression. Compensatory hypertrophic cardiomyopathy, dilated cardiomyopathy, and conduction system abnormalities in FRDA lead t...

Descripción completa

Detalles Bibliográficos
Autores principales: Wong, Andy On-Tik, Wong, Gabriel, Shen, Michael, Chow, Maggie Zi-Ying, Tse, Wan Wai, Gurung, Bimal, Mak, Suet Yee, Lieu, Deborah K., Costa, Kevin D., Chan, Camie W., Martelli, Alain, Nabhan, Joseph F., Li, Ronald A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2019
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6615274/
https://www.ncbi.nlm.nih.gov/pubmed/31286988
http://dx.doi.org/10.1186/s13287-019-1305-y

Ejemplares similares

Ejemplares similares