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Cudrania tricuspidata Extract Protects against Reflux Esophagitis by Blocking H(2) Histamine Receptors

Cudrania tricuspidata has been used in East Asia as a folk medicine for symptoms such as inflammation, allergy, and gastritis. Administration of C. tricuspidata extract to pylori-ligated rat stomachs reduces gastric acid secretion and alleviates esophagus damage caused by gastric reflux. Therefore,...

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Autores principales: Kim, Joo Yun, Jang, Sung Sik, Lee, Jung Lyoul, Sim, Jae-Hun, Shim, Jae-Jung
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Korean Society of Food Science and Nutrition 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6615352/
https://www.ncbi.nlm.nih.gov/pubmed/31328120
http://dx.doi.org/10.3746/pnf.2019.24.2.159
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author Kim, Joo Yun
Jang, Sung Sik
Lee, Jung Lyoul
Sim, Jae-Hun
Shim, Jae-Jung
author_facet Kim, Joo Yun
Jang, Sung Sik
Lee, Jung Lyoul
Sim, Jae-Hun
Shim, Jae-Jung
author_sort Kim, Joo Yun
collection PubMed
description Cudrania tricuspidata has been used in East Asia as a folk medicine for symptoms such as inflammation, allergy, and gastritis. Administration of C. tricuspidata extract to pylori-ligated rat stomachs reduces gastric acid secretion and alleviates esophagus damage caused by gastric reflux. Therefore, in this study we aimed to investigate whether C. tricuspidata extracts inhibit reflux esophagitis by blocking H(2) histamine receptor (H(2)R). Dimaprit, a H(2)R specific agonist, induced intracellular cyclic adenosine monophosphate (cAMP) production in U937 cells. Pretreatment with C. tricuspidata extracts significantly blocked dimaprit-induced cAMP production in a concentration-dependent manner. To extracted C. tricuspidata with different ethanol concentrations to determine the optimum method. We found that the 70% ethanol extract showed the most potent H(2)R antagonistic effect against dimaprit-induced cAMP production. However, water extract did not show any H(2)R blocking effect. These findings suggest that C. tricuspidata extracted using ethanol specifically inhibits gastric acid secretion and reduces esophageal injury by blocking H(2)R in a competitive manner. Therefore, C. tricuspidata extracts may be used in food or medicine to prevent H(2)R-related diseases, such as gastric hyperacidity and reflux esophagitis.
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spelling pubmed-66153522019-07-19 Cudrania tricuspidata Extract Protects against Reflux Esophagitis by Blocking H(2) Histamine Receptors Kim, Joo Yun Jang, Sung Sik Lee, Jung Lyoul Sim, Jae-Hun Shim, Jae-Jung Prev Nutr Food Sci Articles Cudrania tricuspidata has been used in East Asia as a folk medicine for symptoms such as inflammation, allergy, and gastritis. Administration of C. tricuspidata extract to pylori-ligated rat stomachs reduces gastric acid secretion and alleviates esophagus damage caused by gastric reflux. Therefore, in this study we aimed to investigate whether C. tricuspidata extracts inhibit reflux esophagitis by blocking H(2) histamine receptor (H(2)R). Dimaprit, a H(2)R specific agonist, induced intracellular cyclic adenosine monophosphate (cAMP) production in U937 cells. Pretreatment with C. tricuspidata extracts significantly blocked dimaprit-induced cAMP production in a concentration-dependent manner. To extracted C. tricuspidata with different ethanol concentrations to determine the optimum method. We found that the 70% ethanol extract showed the most potent H(2)R antagonistic effect against dimaprit-induced cAMP production. However, water extract did not show any H(2)R blocking effect. These findings suggest that C. tricuspidata extracted using ethanol specifically inhibits gastric acid secretion and reduces esophageal injury by blocking H(2)R in a competitive manner. Therefore, C. tricuspidata extracts may be used in food or medicine to prevent H(2)R-related diseases, such as gastric hyperacidity and reflux esophagitis. The Korean Society of Food Science and Nutrition 2019-06 2019-06-30 /pmc/articles/PMC6615352/ /pubmed/31328120 http://dx.doi.org/10.3746/pnf.2019.24.2.159 Text en Copyright © 2019 by The Korean Society of Food Science and Nutrition This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Articles
Kim, Joo Yun
Jang, Sung Sik
Lee, Jung Lyoul
Sim, Jae-Hun
Shim, Jae-Jung
Cudrania tricuspidata Extract Protects against Reflux Esophagitis by Blocking H(2) Histamine Receptors
title Cudrania tricuspidata Extract Protects against Reflux Esophagitis by Blocking H(2) Histamine Receptors
title_full Cudrania tricuspidata Extract Protects against Reflux Esophagitis by Blocking H(2) Histamine Receptors
title_fullStr Cudrania tricuspidata Extract Protects against Reflux Esophagitis by Blocking H(2) Histamine Receptors
title_full_unstemmed Cudrania tricuspidata Extract Protects against Reflux Esophagitis by Blocking H(2) Histamine Receptors
title_short Cudrania tricuspidata Extract Protects against Reflux Esophagitis by Blocking H(2) Histamine Receptors
title_sort cudrania tricuspidata extract protects against reflux esophagitis by blocking h(2) histamine receptors
topic Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6615352/
https://www.ncbi.nlm.nih.gov/pubmed/31328120
http://dx.doi.org/10.3746/pnf.2019.24.2.159
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