Profound analgesia is associated with a truncated peptide resulting from tissue specific alternative splicing of DRG CA8-204 regulated by an exon-level cis-eQTL

Carbonic anhydrase-8 (CA8) is an intracellular protein that functions as an allosteric inhibitor of inositol trisphosphate receptor-1 (ITPR1) critical to intracellular Ca(++) release, synaptic functions and neuronal excitability. We showed previously that murine nociception and analgesic responses a...

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Detalles Bibliográficos
Autores principales: Upadhyay, Udita, Zhuang, Gerald Z., Diatchenko, Luda, Parisien, Marc, Kang, Yuan, Sarantopoulos, Konstantinos D., Martin, Eden R., Smith, Shad B., Maixner, William, Levitt, Roy C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2019
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6615631/
https://www.ncbi.nlm.nih.gov/pubmed/31199789
http://dx.doi.org/10.1371/journal.pgen.1008226

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6615631/
https://www.ncbi.nlm.nih.gov/pubmed/31199789
http://dx.doi.org/10.1371/journal.pgen.1008226

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