Energetic costs of cellular and therapeutic control of stochastic mitochondrial DNA populations

The dynamics of the cellular proportion of mutant mtDNA molecules is crucial for mitochondrial diseases. Cellular populations of mitochondria are under homeostatic control, but the details of the control mechanisms involved remain elusive. Here, we use stochastic modelling to derive general results...

Descripción completa

Detalles Bibliográficos
Autores principales: Hoitzing, Hanne, Gammage, Payam A., Haute, Lindsey Van, Minczuk, Michal, Johnston, Iain G., Jones, Nick S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2019
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6615642/
https://www.ncbi.nlm.nih.gov/pubmed/31242175
http://dx.doi.org/10.1371/journal.pcbi.1007023

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6615642/
https://www.ncbi.nlm.nih.gov/pubmed/31242175
http://dx.doi.org/10.1371/journal.pcbi.1007023

Ejemplares similares