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Energetic costs of cellular and therapeutic control of stochastic mitochondrial DNA populations
The dynamics of the cellular proportion of mutant mtDNA molecules is crucial for mitochondrial diseases. Cellular populations of mitochondria are under homeostatic control, but the details of the control mechanisms involved remain elusive. Here, we use stochastic modelling to derive general results...
| Autores principales: | , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Public Library of Science
2019
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6615642/ https://www.ncbi.nlm.nih.gov/pubmed/31242175 http://dx.doi.org/10.1371/journal.pcbi.1007023 |