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Mechanisms of resistance to a PI3K inhibitor in gastrointestinal stromal tumors: an omic approach to identify novel druggable targets

Background: Gastrointestinal stromal tumors (GISTs) represent a worldwide paradigm of target therapy. The introduction of tyrosine kinase inhibitors has deeply changed the prognosis of GIST patients, however, the majority of them acquire secondary mutations and progress. Unfortunately, besides tyros...

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Detalles Bibliográficos
Autores principales:	Ravegnini, Gloria, Sammarini, Giulia, Moran, Sebastian, Calice, Giovanni, Indio, Valentina, Urbini, Milena, Astolfi, Annalisa, Zanotti, Federica, Pantaleo, Maria A, Hrelia, Patrizia, Angelini, Sabrina
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Dove 2019
Materias:	Original Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6615718/ https://www.ncbi.nlm.nih.gov/pubmed/31308757 http://dx.doi.org/10.2147/CMAR.S189661

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