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Evaluating the effectiveness and cost-effectiveness of health facility-based and community-based index-linked HIV testing strategies for children: protocol for the B-GAP study in Zimbabwe
INTRODUCTION: The number of new paediatric infections per year has declined in sub-Saharan Africa due to prevention-of-mother-to-child HIV transmission programmes; many children and adolescents living with HIV remain undiagnosed. In this protocol paper, we describe the methodology for evaluating an...
Autores principales: | , , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BMJ Publishing Group
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6615786/ https://www.ncbi.nlm.nih.gov/pubmed/31289091 http://dx.doi.org/10.1136/bmjopen-2019-029428 |
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author | Dziva Chikwari, Chido Simms, Victoria Dringus, Stefanie Kranzer, Katharina Bandason, Tsitsi Vasantharoopan, Arthi Chikodzore, Rudo Sibanda, Edwin Mutseta, Miriam Webb, Karen Engelsmann, Barbara Ncube, Gertrude Mujuru, Hilda Apollo, Tsitsi Weiss, Helen Anne Ferrand, Rashida |
author_facet | Dziva Chikwari, Chido Simms, Victoria Dringus, Stefanie Kranzer, Katharina Bandason, Tsitsi Vasantharoopan, Arthi Chikodzore, Rudo Sibanda, Edwin Mutseta, Miriam Webb, Karen Engelsmann, Barbara Ncube, Gertrude Mujuru, Hilda Apollo, Tsitsi Weiss, Helen Anne Ferrand, Rashida |
author_sort | Dziva Chikwari, Chido |
collection | PubMed |
description | INTRODUCTION: The number of new paediatric infections per year has declined in sub-Saharan Africa due to prevention-of-mother-to-child HIV transmission programmes; many children and adolescents living with HIV remain undiagnosed. In this protocol paper, we describe the methodology for evaluating an index-linked HIV testing approach for children aged 2–18 years in health facility and community settings in Zimbabwe. METHODS AND ANALYSIS: Individuals attending for HIV care at selected primary healthcare clinics (PHCs) will be asked if they have any children aged 2–18 years in their households who have not been tested for HIV. Three options for HIV testing for these children will be offered: testing at the PHC; home-based testing performed by community workers; or an oral mucosal HIV test given to the caregiver to test the children at home. All eligible children will be followed-up to ascertain whether HIV testing occurred. For those who did not test, reasons will be determined, and for those who tested, the HIV test result will be recorded. The primary outcome will be uptake of HIV testing. The secondary outcomes will be preferred HIV testing method, HIV yield, prevalence and proportion of those testing positive linking to care and having an undetectable viral load at 12 months. HIV test results will be stratified by sex and age group, and factors associated with uptake of HIV testing and choice of HIV testing method will be investigated. ETHICS AND DISSEMINATION: Ethical approval for this study was granted by the Medical Research Council of Zimbabwe, the London School of Hygiene and Tropical Medicine and the Institutional Review Board of the Biomedical Research and Training Institute. Study results will be presented at national policy meetings and national and international research conferences. Results will also be published in international peer-reviewed scientific journals and disseminated to study communities at the end of study. |
format | Online Article Text |
id | pubmed-6615786 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | BMJ Publishing Group |
record_format | MEDLINE/PubMed |
spelling | pubmed-66157862019-07-28 Evaluating the effectiveness and cost-effectiveness of health facility-based and community-based index-linked HIV testing strategies for children: protocol for the B-GAP study in Zimbabwe Dziva Chikwari, Chido Simms, Victoria Dringus, Stefanie Kranzer, Katharina Bandason, Tsitsi Vasantharoopan, Arthi Chikodzore, Rudo Sibanda, Edwin Mutseta, Miriam Webb, Karen Engelsmann, Barbara Ncube, Gertrude Mujuru, Hilda Apollo, Tsitsi Weiss, Helen Anne Ferrand, Rashida BMJ Open HIV/AIDS INTRODUCTION: The number of new paediatric infections per year has declined in sub-Saharan Africa due to prevention-of-mother-to-child HIV transmission programmes; many children and adolescents living with HIV remain undiagnosed. In this protocol paper, we describe the methodology for evaluating an index-linked HIV testing approach for children aged 2–18 years in health facility and community settings in Zimbabwe. METHODS AND ANALYSIS: Individuals attending for HIV care at selected primary healthcare clinics (PHCs) will be asked if they have any children aged 2–18 years in their households who have not been tested for HIV. Three options for HIV testing for these children will be offered: testing at the PHC; home-based testing performed by community workers; or an oral mucosal HIV test given to the caregiver to test the children at home. All eligible children will be followed-up to ascertain whether HIV testing occurred. For those who did not test, reasons will be determined, and for those who tested, the HIV test result will be recorded. The primary outcome will be uptake of HIV testing. The secondary outcomes will be preferred HIV testing method, HIV yield, prevalence and proportion of those testing positive linking to care and having an undetectable viral load at 12 months. HIV test results will be stratified by sex and age group, and factors associated with uptake of HIV testing and choice of HIV testing method will be investigated. ETHICS AND DISSEMINATION: Ethical approval for this study was granted by the Medical Research Council of Zimbabwe, the London School of Hygiene and Tropical Medicine and the Institutional Review Board of the Biomedical Research and Training Institute. Study results will be presented at national policy meetings and national and international research conferences. Results will also be published in international peer-reviewed scientific journals and disseminated to study communities at the end of study. BMJ Publishing Group 2019-07-09 /pmc/articles/PMC6615786/ /pubmed/31289091 http://dx.doi.org/10.1136/bmjopen-2019-029428 Text en © Author(s) (or their employer(s)) 2019. Re-use permitted under CC BY. Published by BMJ. This is an open access article distributed in accordance with the Creative Commons Attribution 4.0 Unported (CC BY 4.0) license, which permits others to copy, redistribute, remix, transform and build upon this work for any purpose, provided the original work is properly cited, a link to the licence is given, and indication of whether changes were made. See: https://creativecommons.org/licenses/by/4.0/. |
spellingShingle | HIV/AIDS Dziva Chikwari, Chido Simms, Victoria Dringus, Stefanie Kranzer, Katharina Bandason, Tsitsi Vasantharoopan, Arthi Chikodzore, Rudo Sibanda, Edwin Mutseta, Miriam Webb, Karen Engelsmann, Barbara Ncube, Gertrude Mujuru, Hilda Apollo, Tsitsi Weiss, Helen Anne Ferrand, Rashida Evaluating the effectiveness and cost-effectiveness of health facility-based and community-based index-linked HIV testing strategies for children: protocol for the B-GAP study in Zimbabwe |
title | Evaluating the effectiveness and cost-effectiveness of health facility-based and community-based index-linked HIV testing strategies for children: protocol for the B-GAP study in Zimbabwe |
title_full | Evaluating the effectiveness and cost-effectiveness of health facility-based and community-based index-linked HIV testing strategies for children: protocol for the B-GAP study in Zimbabwe |
title_fullStr | Evaluating the effectiveness and cost-effectiveness of health facility-based and community-based index-linked HIV testing strategies for children: protocol for the B-GAP study in Zimbabwe |
title_full_unstemmed | Evaluating the effectiveness and cost-effectiveness of health facility-based and community-based index-linked HIV testing strategies for children: protocol for the B-GAP study in Zimbabwe |
title_short | Evaluating the effectiveness and cost-effectiveness of health facility-based and community-based index-linked HIV testing strategies for children: protocol for the B-GAP study in Zimbabwe |
title_sort | evaluating the effectiveness and cost-effectiveness of health facility-based and community-based index-linked hiv testing strategies for children: protocol for the b-gap study in zimbabwe |
topic | HIV/AIDS |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6615786/ https://www.ncbi.nlm.nih.gov/pubmed/31289091 http://dx.doi.org/10.1136/bmjopen-2019-029428 |
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