Cargando…

Dose–response associations between metabolic indexes and the risk of comorbid type 2 diabetes mellitus among rheumatoid arthritis patients from Northern China: a case–control study

OBJECTIVE: To investigate whether there were any differences in the patterns of metabolic abnormalities between patients with rheumatoid arthritis (RA) with comorbid type 2 diabetes mellitus (T2DM) and other populations, and to plot the dose–response relationships between metabolic indexes and the r...

Descripción completa

Detalles Bibliográficos
Autores principales: Li, Guangxiao, Chi, Weijun, Bai, Bingqing, Li, Ying, Wei, Tingting, Fu, Lingyu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BMJ Publishing Group 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6615834/
https://www.ncbi.nlm.nih.gov/pubmed/31278101
http://dx.doi.org/10.1136/bmjopen-2018-028011
_version_ 1783433408841515008
author Li, Guangxiao
Chi, Weijun
Bai, Bingqing
Li, Ying
Wei, Tingting
Fu, Lingyu
author_facet Li, Guangxiao
Chi, Weijun
Bai, Bingqing
Li, Ying
Wei, Tingting
Fu, Lingyu
author_sort Li, Guangxiao
collection PubMed
description OBJECTIVE: To investigate whether there were any differences in the patterns of metabolic abnormalities between patients with rheumatoid arthritis (RA) with comorbid type 2 diabetes mellitus (T2DM) and other populations, and to plot the dose–response relationships between metabolic indexes and the risk of comorbid T2DM among patients with RA. DESIGN AND SETTING: This is a retrospective case–control study using electronic medical records (EMRs). Patients with RA and/or T2DM or controls who were admitted to the First Affiliated Hospital of China Medical University between April 2008 and December 2016 were retrospectively recruited through the EMR system. After age-matching and sex-matching, 261 controls, 274 patients with T2DM, 276 patients with RA and 151 patients with RA+T2DM were eventually recruited. RESULTS: Patients with RA+T2DM exhibited higher levels of systolic blood pressure (SBP), fasting plasma glucose (FPG) and triglyceride (TG) than the RA only patients. Moreover, the proportions of impaired fasting glucose (IFG), and total cholesterol (TC) and low-density lipoprotein cholesterol (LDL-C) dyslipidaemia in the RA+T2DM group were higher than those in the RA alone group (for IFG: 28.48% vs 18.84%, p=0.02; for TC: 25.17% vs 15.22%, p=0.01; for LDL-C: 25.83% vs 17.03%; p=0.03). Rheumatoid factor (RF) positivity and IFG were independent risk indicators for comorbid T2DM among patients with RA (for RF positivity: OR=0.45; 95% CI: 0.29 to 0.69; p<0.001; for IFG: OR=1.70; 95% CI: 1.04 to 2.76; p=0.03). CONCLUSION: Linear dose–response associations between SBP, TC, TG and the risk of comorbid T2DM among patients with RA were observed, whereas a non-linear dose–response association between FPG and the risk of comorbid T2DM was found. Patients with RA+T2DM were more likely to exhibit metabolic abnormalities than RA only patients. Patients with RA+T2DM with metabolic abnormalities deserve more attention from rheumatologists and endocrinologists.
format Online
Article
Text
id pubmed-6615834
institution National Center for Biotechnology Information
language English
publishDate 2019
publisher BMJ Publishing Group
record_format MEDLINE/PubMed
spelling pubmed-66158342019-07-28 Dose–response associations between metabolic indexes and the risk of comorbid type 2 diabetes mellitus among rheumatoid arthritis patients from Northern China: a case–control study Li, Guangxiao Chi, Weijun Bai, Bingqing Li, Ying Wei, Tingting Fu, Lingyu BMJ Open Rheumatology OBJECTIVE: To investigate whether there were any differences in the patterns of metabolic abnormalities between patients with rheumatoid arthritis (RA) with comorbid type 2 diabetes mellitus (T2DM) and other populations, and to plot the dose–response relationships between metabolic indexes and the risk of comorbid T2DM among patients with RA. DESIGN AND SETTING: This is a retrospective case–control study using electronic medical records (EMRs). Patients with RA and/or T2DM or controls who were admitted to the First Affiliated Hospital of China Medical University between April 2008 and December 2016 were retrospectively recruited through the EMR system. After age-matching and sex-matching, 261 controls, 274 patients with T2DM, 276 patients with RA and 151 patients with RA+T2DM were eventually recruited. RESULTS: Patients with RA+T2DM exhibited higher levels of systolic blood pressure (SBP), fasting plasma glucose (FPG) and triglyceride (TG) than the RA only patients. Moreover, the proportions of impaired fasting glucose (IFG), and total cholesterol (TC) and low-density lipoprotein cholesterol (LDL-C) dyslipidaemia in the RA+T2DM group were higher than those in the RA alone group (for IFG: 28.48% vs 18.84%, p=0.02; for TC: 25.17% vs 15.22%, p=0.01; for LDL-C: 25.83% vs 17.03%; p=0.03). Rheumatoid factor (RF) positivity and IFG were independent risk indicators for comorbid T2DM among patients with RA (for RF positivity: OR=0.45; 95% CI: 0.29 to 0.69; p<0.001; for IFG: OR=1.70; 95% CI: 1.04 to 2.76; p=0.03). CONCLUSION: Linear dose–response associations between SBP, TC, TG and the risk of comorbid T2DM among patients with RA were observed, whereas a non-linear dose–response association between FPG and the risk of comorbid T2DM was found. Patients with RA+T2DM were more likely to exhibit metabolic abnormalities than RA only patients. Patients with RA+T2DM with metabolic abnormalities deserve more attention from rheumatologists and endocrinologists. BMJ Publishing Group 2019-07-04 /pmc/articles/PMC6615834/ /pubmed/31278101 http://dx.doi.org/10.1136/bmjopen-2018-028011 Text en © Author(s) (or their employer(s)) 2019. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ. This is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited, appropriate credit is given, any changes made indicated, and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/.
spellingShingle Rheumatology
Li, Guangxiao
Chi, Weijun
Bai, Bingqing
Li, Ying
Wei, Tingting
Fu, Lingyu
Dose–response associations between metabolic indexes and the risk of comorbid type 2 diabetes mellitus among rheumatoid arthritis patients from Northern China: a case–control study
title Dose–response associations between metabolic indexes and the risk of comorbid type 2 diabetes mellitus among rheumatoid arthritis patients from Northern China: a case–control study
title_full Dose–response associations between metabolic indexes and the risk of comorbid type 2 diabetes mellitus among rheumatoid arthritis patients from Northern China: a case–control study
title_fullStr Dose–response associations between metabolic indexes and the risk of comorbid type 2 diabetes mellitus among rheumatoid arthritis patients from Northern China: a case–control study
title_full_unstemmed Dose–response associations between metabolic indexes and the risk of comorbid type 2 diabetes mellitus among rheumatoid arthritis patients from Northern China: a case–control study
title_short Dose–response associations between metabolic indexes and the risk of comorbid type 2 diabetes mellitus among rheumatoid arthritis patients from Northern China: a case–control study
title_sort dose–response associations between metabolic indexes and the risk of comorbid type 2 diabetes mellitus among rheumatoid arthritis patients from northern china: a case–control study
topic Rheumatology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6615834/
https://www.ncbi.nlm.nih.gov/pubmed/31278101
http://dx.doi.org/10.1136/bmjopen-2018-028011
work_keys_str_mv AT liguangxiao doseresponseassociationsbetweenmetabolicindexesandtheriskofcomorbidtype2diabetesmellitusamongrheumatoidarthritispatientsfromnorthernchinaacasecontrolstudy
AT chiweijun doseresponseassociationsbetweenmetabolicindexesandtheriskofcomorbidtype2diabetesmellitusamongrheumatoidarthritispatientsfromnorthernchinaacasecontrolstudy
AT baibingqing doseresponseassociationsbetweenmetabolicindexesandtheriskofcomorbidtype2diabetesmellitusamongrheumatoidarthritispatientsfromnorthernchinaacasecontrolstudy
AT liying doseresponseassociationsbetweenmetabolicindexesandtheriskofcomorbidtype2diabetesmellitusamongrheumatoidarthritispatientsfromnorthernchinaacasecontrolstudy
AT weitingting doseresponseassociationsbetweenmetabolicindexesandtheriskofcomorbidtype2diabetesmellitusamongrheumatoidarthritispatientsfromnorthernchinaacasecontrolstudy
AT fulingyu doseresponseassociationsbetweenmetabolicindexesandtheriskofcomorbidtype2diabetesmellitusamongrheumatoidarthritispatientsfromnorthernchinaacasecontrolstudy