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KHNYN is essential for the zinc finger antiviral protein (ZAP) to restrict HIV-1 containing clustered CpG dinucleotides

CpG dinucleotides are suppressed in most vertebrate RNA viruses, including HIV-1, and introducing CpGs into RNA virus genomes inhibits their replication. The zinc finger antiviral protein (ZAP) binds regions of viral RNA containing CpGs and targets them for degradation. ZAP does not have enzymatic a...

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Detalles Bibliográficos
Autores principales:	Ficarelli, Mattia, Wilson, Harry, Pedro Galão, Rui, Mazzon, Michela, Antzin-Anduetza, Irati, Marsh, Mark, Neil, Stuart JD, Swanson, Chad M
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	eLife Sciences Publications, Ltd 2019
Materias:	Immunology and Inflammation
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6615859/ https://www.ncbi.nlm.nih.gov/pubmed/31284899 http://dx.doi.org/10.7554/eLife.46767

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