A Case of Pneumatosis Intestinalis With Pneumoperitoneum as a Potential Delayed Adverse Effect of Capecitabine

Ileitis and colitis are known complications of capecitabine when used in patients with gastrointestinal cancers. However, to our knowledge, pneumatosis intestinalis (PI) has not previously been reported with this medication. We present a patient with breast cancer, without any metastases to the gast...

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Detalles Bibliográficos
Autores principales: Khan, Taimoor, Mujtaba, Mohamed, Flores, Marcus S., Nahum, Kenneth, Carson, Michael P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elmer Press 2019
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6615914/
https://www.ncbi.nlm.nih.gov/pubmed/31312282
http://dx.doi.org/10.14740/wjon1186
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author Khan, Taimoor
Mujtaba, Mohamed
Flores, Marcus S.
Nahum, Kenneth
Carson, Michael P.
author_facet Khan, Taimoor
Mujtaba, Mohamed
Flores, Marcus S.
Nahum, Kenneth
Carson, Michael P.
author_sort Khan, Taimoor
collection PubMed
description Ileitis and colitis are known complications of capecitabine when used in patients with gastrointestinal cancers. However, to our knowledge, pneumatosis intestinalis (PI) has not previously been reported with this medication. We present a patient with breast cancer, without any metastases to the gastrointestinal tract, who presented with persistent diarrhea 4 weeks after discontinuing adjuvant capecitabine, which was found to be due to PI. As she had no other risk factors or identifiable causes, her PI was attributed to a delayed reaction to capecitabine. This case highlights the need to consider PI earlier in the differential diagnosis in patients with breast cancer who present with unexplained diarrhea after recent discontinuation of capecitabine.
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spelling pubmed-66159142019-07-16 A Case of Pneumatosis Intestinalis With Pneumoperitoneum as a Potential Delayed Adverse Effect of Capecitabine Khan, Taimoor Mujtaba, Mohamed Flores, Marcus S. Nahum, Kenneth Carson, Michael P. World J Oncol Case Report Ileitis and colitis are known complications of capecitabine when used in patients with gastrointestinal cancers. However, to our knowledge, pneumatosis intestinalis (PI) has not previously been reported with this medication. We present a patient with breast cancer, without any metastases to the gastrointestinal tract, who presented with persistent diarrhea 4 weeks after discontinuing adjuvant capecitabine, which was found to be due to PI. As she had no other risk factors or identifiable causes, her PI was attributed to a delayed reaction to capecitabine. This case highlights the need to consider PI earlier in the differential diagnosis in patients with breast cancer who present with unexplained diarrhea after recent discontinuation of capecitabine. Elmer Press 2019-06 2019-06-29 /pmc/articles/PMC6615914/ /pubmed/31312282 http://dx.doi.org/10.14740/wjon1186 Text en Copyright 2019, Khan et al. http://creativecommons.org/licenses/by-nc/4.0/ This article is distributed under the terms of the Creative Commons Attribution Non-Commercial 4.0 International License, which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Case Report
Khan, Taimoor
Mujtaba, Mohamed
Flores, Marcus S.
Nahum, Kenneth
Carson, Michael P.
A Case of Pneumatosis Intestinalis With Pneumoperitoneum as a Potential Delayed Adverse Effect of Capecitabine
title A Case of Pneumatosis Intestinalis With Pneumoperitoneum as a Potential Delayed Adverse Effect of Capecitabine
title_full A Case of Pneumatosis Intestinalis With Pneumoperitoneum as a Potential Delayed Adverse Effect of Capecitabine
title_fullStr A Case of Pneumatosis Intestinalis With Pneumoperitoneum as a Potential Delayed Adverse Effect of Capecitabine
title_full_unstemmed A Case of Pneumatosis Intestinalis With Pneumoperitoneum as a Potential Delayed Adverse Effect of Capecitabine
title_short A Case of Pneumatosis Intestinalis With Pneumoperitoneum as a Potential Delayed Adverse Effect of Capecitabine
title_sort case of pneumatosis intestinalis with pneumoperitoneum as a potential delayed adverse effect of capecitabine
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6615914/
https://www.ncbi.nlm.nih.gov/pubmed/31312282
http://dx.doi.org/10.14740/wjon1186
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