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Adenylyl cyclase-associated protein 1-targeted nanoparticles as a novel strategy for the treatment of metastatic non-small cell lung cancer
Non-small cell lung cancer (NSCLC) is one of the most fatal cancers worldwide. Adenylyl cyclase-associated protein 1 (CAP1) belongs to a family of cyclase-associated proteins that are involved in the development of cancerous tumors. A previous study by our group confirmed the association between CAP...
Autores principales: | , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
D.A. Spandidos
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6615927/ https://www.ncbi.nlm.nih.gov/pubmed/31173184 http://dx.doi.org/10.3892/ijo.2019.4822 |
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author | Liu, Yang Xie, Shuanshuan Zeng, Jie Song, Xiaolian Tan, Min He, Dannong Wang, Jie Wang, Ping Zhu, Jun Wang, Changhui |
author_facet | Liu, Yang Xie, Shuanshuan Zeng, Jie Song, Xiaolian Tan, Min He, Dannong Wang, Jie Wang, Ping Zhu, Jun Wang, Changhui |
author_sort | Liu, Yang |
collection | PubMed |
description | Non-small cell lung cancer (NSCLC) is one of the most fatal cancers worldwide. Adenylyl cyclase-associated protein 1 (CAP1) belongs to a family of cyclase-associated proteins that are involved in the development of cancerous tumors. A previous study by our group confirmed the association between CAP1, lung cancer and the metastasis of cancer cells. In the present study, poly(lactic-polyglycolic acid; PLGA)/CAP1-small interfering (si)RNA nanoparticles were prepared and delivered into A549 cells. The performance of PLGA/siCAP1-siRNA nanoparticles for siRNA delivery was measured based on the results of migration assay and animal experiments. The multifunctional nanoparticles were determined to be capable of inhibiting CAP1 expression, which reduced NSCLC metastasis in vitro and in vivo. Therefore, the findings of the current study highlighted the potential use of PLGA/siCAP1-siRNA nanoparticles for the treatment of NSCLC metastasis. |
format | Online Article Text |
id | pubmed-6615927 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | D.A. Spandidos |
record_format | MEDLINE/PubMed |
spelling | pubmed-66159272019-07-30 Adenylyl cyclase-associated protein 1-targeted nanoparticles as a novel strategy for the treatment of metastatic non-small cell lung cancer Liu, Yang Xie, Shuanshuan Zeng, Jie Song, Xiaolian Tan, Min He, Dannong Wang, Jie Wang, Ping Zhu, Jun Wang, Changhui Int J Oncol Articles Non-small cell lung cancer (NSCLC) is one of the most fatal cancers worldwide. Adenylyl cyclase-associated protein 1 (CAP1) belongs to a family of cyclase-associated proteins that are involved in the development of cancerous tumors. A previous study by our group confirmed the association between CAP1, lung cancer and the metastasis of cancer cells. In the present study, poly(lactic-polyglycolic acid; PLGA)/CAP1-small interfering (si)RNA nanoparticles were prepared and delivered into A549 cells. The performance of PLGA/siCAP1-siRNA nanoparticles for siRNA delivery was measured based on the results of migration assay and animal experiments. The multifunctional nanoparticles were determined to be capable of inhibiting CAP1 expression, which reduced NSCLC metastasis in vitro and in vivo. Therefore, the findings of the current study highlighted the potential use of PLGA/siCAP1-siRNA nanoparticles for the treatment of NSCLC metastasis. D.A. Spandidos 2019-06-06 /pmc/articles/PMC6615927/ /pubmed/31173184 http://dx.doi.org/10.3892/ijo.2019.4822 Text en Copyright: © Liu et al. This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License (https://creativecommons.org/licenses/by-nc-nd/4.0/) , which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made. |
spellingShingle | Articles Liu, Yang Xie, Shuanshuan Zeng, Jie Song, Xiaolian Tan, Min He, Dannong Wang, Jie Wang, Ping Zhu, Jun Wang, Changhui Adenylyl cyclase-associated protein 1-targeted nanoparticles as a novel strategy for the treatment of metastatic non-small cell lung cancer |
title | Adenylyl cyclase-associated protein 1-targeted nanoparticles as a novel strategy for the treatment of metastatic non-small cell lung cancer |
title_full | Adenylyl cyclase-associated protein 1-targeted nanoparticles as a novel strategy for the treatment of metastatic non-small cell lung cancer |
title_fullStr | Adenylyl cyclase-associated protein 1-targeted nanoparticles as a novel strategy for the treatment of metastatic non-small cell lung cancer |
title_full_unstemmed | Adenylyl cyclase-associated protein 1-targeted nanoparticles as a novel strategy for the treatment of metastatic non-small cell lung cancer |
title_short | Adenylyl cyclase-associated protein 1-targeted nanoparticles as a novel strategy for the treatment of metastatic non-small cell lung cancer |
title_sort | adenylyl cyclase-associated protein 1-targeted nanoparticles as a novel strategy for the treatment of metastatic non-small cell lung cancer |
topic | Articles |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6615927/ https://www.ncbi.nlm.nih.gov/pubmed/31173184 http://dx.doi.org/10.3892/ijo.2019.4822 |
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