Loss of SRSF3 in Cardiomyocytes Leads to Decapping of Contraction-Related mRNAs and Severe Systolic Dysfunction

RATIONALE: RBPs (RNA binding proteins) play critical roles in the cell by regulating mRNA transport, splicing, editing, and stability. The RBP SRSF3 (serine/arginine-rich splicing factor 3) is essential for blastocyst formation and for proper liver development and function. However, its role in the...

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Detalles Bibliográficos
Autores principales: Ortiz-Sánchez, Paula, Villalba-Orero, María, López-Olañeta, Marina M., Larrasa-Alonso, Javier, Sánchez-Cabo, Fátima, Martí-Gómez, Carlos, Camafeita, Emilio, Gómez-Salinero, Jesús M., Ramos-Hernández, Laura, Nielsen, Peter J., Vázquez, Jesús, Müller-McNicoll, Michaela, García-Pavía, Pablo, Lara-Pezzi, Enrique
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Lippincott Williams & Wilkins 2019
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6615931/
https://www.ncbi.nlm.nih.gov/pubmed/31145021
http://dx.doi.org/10.1161/CIRCRESAHA.118.314515

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