Cargando…

Combining use of Phillyrin and autophagy blocker alleviates laryngeal squamous cell carcinoma via AMPK/mTOR/p70S6K signaling

Phillyrin (PHN), one of the major active constituents of Forsythia suspensa and F. koreana, has been reported to produce antioxidant, antibacterial, anti-obesity and anti-inflammatory effects. However, no study has demonstrated the role of PHN in laryngeal squamous cell carcinoma (LSCC). We aimed to...

Descripción completa

Detalles Bibliográficos
Autores principales:	Wang, Da-hua, He, Xi, He, Qing
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Portland Press Ltd. 2019
Materias:	Research Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6616054/ https://www.ncbi.nlm.nih.gov/pubmed/31147451 http://dx.doi.org/10.1042/BSR20190459

Ejemplares similares

Dapagliflozin Alleviates Hepatic Steatosis by Restoring Autophagy via the AMPK-mTOR Pathway
por: Li, Liuran, et al.
Publicado: (2021)

Eugenol Attenuates Cerebral Ischemia-Reperfusion Injury by Enhancing Autophagy via AMPK-mTOR-P70S6K Pathway
por: Sun, Xiaowei, et al.
Publicado: (2020)

Isoquercitrin induces apoptosis and autophagy in hepatocellular carcinoma cells via AMPK/mTOR/p70S6K signaling pathway
por: Shui, Liyan, et al.
Publicado: (2020)

Adrenomedullin alleviates the pyroptosis of Leydig cells by promoting autophagy via the ROS–AMPK–mTOR axis
por: Li, Ming-yong, et al.
Publicado: (2019)

Cordycepin inhibits cell senescence by ameliorating lysosomal dysfunction and inducing autophagy through the AMPK and mTOR–p70S6K pathway
por: Zuo, Shi Qi, et al.
Publicado: (2021)

Fingolimod suppresses neuronal autophagy through the mTOR/p70S6K pathway and alleviates ischemic brain damage in mice
por: Li, Xiao, et al.
Publicado: (2017)

Allicin promotes autophagy and ferroptosis in esophageal squamous cell carcinoma by activating AMPK/mTOR signaling
por: Guo, Zhanfang, et al.
Publicado: (2022)

Metformin alleviates β-glycerophosphate-induced calcification of vascular smooth muscle cells via AMPK/mTOR-activated autophagy
por: Qiu, Xiaobo, et al.
Publicado: (2021)

Moderate-intensity exercise alleviates pyroptosis by promoting autophagy in osteoarthritis via the P2X7/AMPK/mTOR axis
por: Li, Zihao, et al.
Publicado: (2021)

Cannabinoid receptor 2 deletion deteriorates myocardial infarction through the down-regulation of AMPK-mTOR-p70S6K signaling-mediated autophagy
por: Hu, Yao, et al.
Publicado: (2019)

Dual inhibition of autophagy and PI3K/mTOR pathway as a potential therapeutic strategy against laryngeal squamous cell carcinoma
por: Huang, Hui-Ying, et al.
Publicado: (2022)

Astragaloside IV alleviates liver injury in type 2 diabetes due to promotion of AMPK/mTOR-mediated autophagy
por: Zhu, Yunfeng, et al.
Publicado: (2021)

Phellodendrine promotes autophagy by regulating the AMPK/mTOR pathway and treats ulcerative colitis
por: Su, Shuai, et al.
Publicado: (2021)

Electroacupuncture alleviates neuropathic pain caused by spared nerve injury by promoting AMPK/mTOR-mediated autophagy in dorsal root ganglion macrophage
por: Xu, Qian, et al.
Publicado: (2022)

Sinomenine ester derivative inhibits glioblastoma by inducing mitochondria-dependent apoptosis and autophagy by PI3K/AKT/mTOR and AMPK/mTOR pathway
por: Zheng, Xiangjin, et al.
Publicado: (2021)

Berberine alleviates ox-LDL induced inflammatory factors by up-regulation of autophagy via AMPK/mTOR signaling pathway
por: Fan, Xiaodi, et al.
Publicado: (2015)

Zhuanggu Zhitong Capsule alleviates postmenopausal osteoporosis in ovariectomized rats by regulating autophagy through AMPK/mTOR signaling pathway
por: Men, Zhitao, et al.
Publicado: (2022)

Curcumin Alleviates D-Galactose-Induced Cardiomyocyte Senescence by Promoting Autophagy via the SIRT1/AMPK/mTOR Pathway
por: Yang, Lei, et al.
Publicado: (2022)

Review on the Pharmacological Properties of Phillyrin
por: Zhou, Chenyu, et al.
Publicado: (2022)

Duck Tembusu virus induces incomplete autophagy via the ERK/mTOR and AMPK/mTOR signalling pathways to promote viral replication in neuronal cells
por: Wang, Qing, et al.
Publicado: (2023)

Autophagy activated by tuberin/mTOR/p70S6K suppression is a protective mechanism against local anaesthetics neurotoxicity
por: Xiong, Jingwei, et al.
Publicado: (2016)

PI3K/AKT/mTOR/p70S6K Pathway Is Involved in Aβ25-35-Induced Autophagy
por: Fan, Shengnuo, et al.
Publicado: (2015)

Alpinia katsumadai Hayata induces growth inhibition and autophagy-related apoptosis by regulating the AMPK and Akt/mTOR/p70S6K signaling pathways in cancer cells
por: An, Weixiao, et al.
Publicado: (2022)

Thymol Alleviates LPS-Induced Liver Inflammation and Apoptosis by Inhibiting NLRP3 Inflammasome Activation and the AMPK-mTOR-Autophagy Pathway
por: Dou, Xiujing, et al.
Publicado: (2022)

Berberine induces autophagy in glioblastoma by targeting the AMPK/mTOR/ULK1-pathway
por: Wang, Jiwei, et al.
Publicado: (2016)

AMPK–mTOR–Mediated Activation of Autophagy Promotes Formation of Dormant Polyploid Giant Cancer Cells
por: You, Bo, et al.
Publicado: (2022)

Natural Cyclopeptide RA-XII, a New Autophagy Inhibitor, Suppresses Protective Autophagy for Enhancing Apoptosis through AMPK/mTOR/P70S6K Pathways in HepG2 Cells
por: Song, Lihua, et al.
Publicado: (2017)

circPARD3 drives malignant progression and chemoresistance of laryngeal squamous cell carcinoma by inhibiting autophagy through the PRKCI-Akt-mTOR pathway
por: Gao, Wei, et al.
Publicado: (2020)

Exogenous H(2)S Protects against Septic Cardiomyopathy by Inhibiting Autophagy through the AMPK/mTOR Pathway
por: Zhao, YuHan, et al.
Publicado: (2022)

Icariin alleviates osteoarthritis by regulating autophagy of chondrocytes by mediating PI3K/AKT/mTOR signaling
por: Tang, Yanghua, et al.
Publicado: (2021)

Ononin alleviates H(2)O(2)-induced cardiomyocyte apoptosis and improves cardiac function by activating the AMPK/mTOR/autophagy pathway
por: Pan, Rongrong, et al.
Publicado: (2021)

The protective roles of allicin on type 1 diabetes mellitus through AMPK/mTOR mediated autophagy pathway
por: Qian, Rengcheng, et al.
Publicado: (2023)

Rhein Inhibits Autophagy in Rat Renal Tubular Cells by Regulation of AMPK/mTOR Signaling
por: Tu, Yue, et al.
Publicado: (2017)

Salmonella Typhimurium disrupts Sirt1/AMPK checkpoint control of mTOR to impair autophagy
por: Ganesan, Raja, et al.
Publicado: (2017)

Trifolirhizin induces autophagy-dependent apoptosis in colon cancer via AMPK/mTOR signaling
por: Sun, Dongdong, et al.
Publicado: (2020)

Trimetazidine ameliorates sunitinib-induced cardiotoxicity in mice via the AMPK/mTOR/autophagy pathway
por: Yang, Yi, et al.
Publicado: (2019)

AMPK/mTOR Signaling in Autophagy Regulation During Cisplatin-Induced Acute Kidney Injury
por: Wang, Ying, et al.
Publicado: (2020)

Antagonizing circRNA_002581–miR-122–CPEB1 axis alleviates NASH through restoring PTEN–AMPK–mTOR pathway regulated autophagy
por: Jin, Xi, et al.
Publicado: (2020)

Polydatin regulates proliferation, apoptosis and autophagy in multiple myeloma cells through mTOR/p70s6k pathway
por: Yang, Baojun, et al.
Publicado: (2017)

mTOR, autophagy, and reprogramming
por: Tang, Bor Luen
Publicado: (2014)

Cannot write session to /tmp/vufind_sessions/sess_1qgper80a9ejtir73itnul0dh1