Role of the Microbiota in the Modulation of Vaccine Immune Responses

The human immune system and the microbiota co-evolve, and their balanced relationship is based on crosstalk between the two systems through the course of life. This tight association and the overall composition and richness of the microbiota play an important role in the modulation of host immunity...

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Autores principales: Ciabattini, Annalisa, Olivieri, Raffaela, Lazzeri, Elisa, Medaglini, Donata
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2019
Materias:
Microbiology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6616116/
https://www.ncbi.nlm.nih.gov/pubmed/31333592
http://dx.doi.org/10.3389/fmicb.2019.01305
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author Ciabattini, Annalisa
Olivieri, Raffaela
Lazzeri, Elisa
Medaglini, Donata
author_facet Ciabattini, Annalisa
Olivieri, Raffaela
Lazzeri, Elisa
Medaglini, Donata
author_sort Ciabattini, Annalisa
collection PubMed
description The human immune system and the microbiota co-evolve, and their balanced relationship is based on crosstalk between the two systems through the course of life. This tight association and the overall composition and richness of the microbiota play an important role in the modulation of host immunity and may impact the immune response to vaccination. The availability of innovative technologies, such as next-generation sequencing (NGS) and correlated bioinformatics tools, allows a deeper investigation of the crosstalk between the microbiota and human immune responses. This review discusses the current knowledge on the influence of the microbiota on the immune response to vaccination and novel tools to deeply analyze the impact of the microbiome on vaccine responses.
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spelling pubmed-66161162019-07-22 Role of the Microbiota in the Modulation of Vaccine Immune Responses Ciabattini, Annalisa Olivieri, Raffaela Lazzeri, Elisa Medaglini, Donata Front Microbiol Microbiology The human immune system and the microbiota co-evolve, and their balanced relationship is based on crosstalk between the two systems through the course of life. This tight association and the overall composition and richness of the microbiota play an important role in the modulation of host immunity and may impact the immune response to vaccination. The availability of innovative technologies, such as next-generation sequencing (NGS) and correlated bioinformatics tools, allows a deeper investigation of the crosstalk between the microbiota and human immune responses. This review discusses the current knowledge on the influence of the microbiota on the immune response to vaccination and novel tools to deeply analyze the impact of the microbiome on vaccine responses. Frontiers Media S.A. 2019-07-03 /pmc/articles/PMC6616116/ /pubmed/31333592 http://dx.doi.org/10.3389/fmicb.2019.01305 Text en Copyright © 2019 Ciabattini, Olivieri, Lazzeri and Medaglini. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Microbiology
Ciabattini, Annalisa
Olivieri, Raffaela
Lazzeri, Elisa
Medaglini, Donata
Role of the Microbiota in the Modulation of Vaccine Immune Responses
title Role of the Microbiota in the Modulation of Vaccine Immune Responses
title_full Role of the Microbiota in the Modulation of Vaccine Immune Responses
title_fullStr Role of the Microbiota in the Modulation of Vaccine Immune Responses
title_full_unstemmed Role of the Microbiota in the Modulation of Vaccine Immune Responses
title_short Role of the Microbiota in the Modulation of Vaccine Immune Responses
title_sort role of the microbiota in the modulation of vaccine immune responses
topic Microbiology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6616116/
https://www.ncbi.nlm.nih.gov/pubmed/31333592
http://dx.doi.org/10.3389/fmicb.2019.01305
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