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Alteration of Pressure-Induced Vasodilation in Aging and Diabetes, a Neuro-Vascular Damage

Skin is constantly subjected to pressure at different levels. Pressure-induced vasodilation (PIV) is one of the response mechanisms to low pressure that maintains the homeostasis of the skin. PIV results from the interaction of primary afferent nerves and vascular endothelium of skin vessels. Thanks...

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Autores principales: Fouchard, Maxime, Misery, Laurent, Le Garrec, Raphaële, Sigaudo-Roussel, Dominique, Fromy, Bérengère
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6616153/
https://www.ncbi.nlm.nih.gov/pubmed/31333501
http://dx.doi.org/10.3389/fphys.2019.00862
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author Fouchard, Maxime
Misery, Laurent
Le Garrec, Raphaële
Sigaudo-Roussel, Dominique
Fromy, Bérengère
author_facet Fouchard, Maxime
Misery, Laurent
Le Garrec, Raphaële
Sigaudo-Roussel, Dominique
Fromy, Bérengère
author_sort Fouchard, Maxime
collection PubMed
description Skin is constantly subjected to pressure at different levels. Pressure-induced vasodilation (PIV) is one of the response mechanisms to low pressure that maintains the homeostasis of the skin. PIV results from the interaction of primary afferent nerves and vascular endothelium of skin vessels. Thanks to this cutaneous neuro-vascular interaction, the cutaneous blood flow increase allows the maintenance of an optimal level of oxygenation and minimizes the lack of vascularization of the skin tissue under low pressure. It seems to be associated with the cutaneous protection mechanisms to prevent pressure ulcers. In some contexts, where microangiopathy and neuropathy can occur, such as aging and diabetes, PIV is impaired, leading to a dramatic early decrease in local skin blood flow when low pressure is applied. In aging, PIV alteration is due to endothelial dysfunction, essentially from an alteration of the nitric oxide pathway. In the inflamm-aging context, oxidative stress increases leading to endothelial cell and nerve damages. An age-related sensory neuropathy will exacerbate the alteration of PIV during the aging process. In diabetes, non-controlled hyperglycaemia leads to an increase in several pathological biochemical pathways that involve oxidative stress and can affect PIV. Sorbinil, alagebrium and alpha-lipoic acid are able individually to restore PIV through a possible oxidative stress reduction. Candesartan, an angiotensin II type 1 receptor blocker, is also able to restore PIV and prevent pressure ulcer formation. The possibility of preventing pressure ulcer associated to diabetes and/or aging with the restoration of PIV seems to be a promising research path.
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spelling pubmed-66161532019-07-22 Alteration of Pressure-Induced Vasodilation in Aging and Diabetes, a Neuro-Vascular Damage Fouchard, Maxime Misery, Laurent Le Garrec, Raphaële Sigaudo-Roussel, Dominique Fromy, Bérengère Front Physiol Physiology Skin is constantly subjected to pressure at different levels. Pressure-induced vasodilation (PIV) is one of the response mechanisms to low pressure that maintains the homeostasis of the skin. PIV results from the interaction of primary afferent nerves and vascular endothelium of skin vessels. Thanks to this cutaneous neuro-vascular interaction, the cutaneous blood flow increase allows the maintenance of an optimal level of oxygenation and minimizes the lack of vascularization of the skin tissue under low pressure. It seems to be associated with the cutaneous protection mechanisms to prevent pressure ulcers. In some contexts, where microangiopathy and neuropathy can occur, such as aging and diabetes, PIV is impaired, leading to a dramatic early decrease in local skin blood flow when low pressure is applied. In aging, PIV alteration is due to endothelial dysfunction, essentially from an alteration of the nitric oxide pathway. In the inflamm-aging context, oxidative stress increases leading to endothelial cell and nerve damages. An age-related sensory neuropathy will exacerbate the alteration of PIV during the aging process. In diabetes, non-controlled hyperglycaemia leads to an increase in several pathological biochemical pathways that involve oxidative stress and can affect PIV. Sorbinil, alagebrium and alpha-lipoic acid are able individually to restore PIV through a possible oxidative stress reduction. Candesartan, an angiotensin II type 1 receptor blocker, is also able to restore PIV and prevent pressure ulcer formation. The possibility of preventing pressure ulcer associated to diabetes and/or aging with the restoration of PIV seems to be a promising research path. Frontiers Media S.A. 2019-07-03 /pmc/articles/PMC6616153/ /pubmed/31333501 http://dx.doi.org/10.3389/fphys.2019.00862 Text en Copyright © 2019 Fouchard, Misery, Le Garrec, Sigaudo-Roussel and Fromy. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Physiology
Fouchard, Maxime
Misery, Laurent
Le Garrec, Raphaële
Sigaudo-Roussel, Dominique
Fromy, Bérengère
Alteration of Pressure-Induced Vasodilation in Aging and Diabetes, a Neuro-Vascular Damage
title Alteration of Pressure-Induced Vasodilation in Aging and Diabetes, a Neuro-Vascular Damage
title_full Alteration of Pressure-Induced Vasodilation in Aging and Diabetes, a Neuro-Vascular Damage
title_fullStr Alteration of Pressure-Induced Vasodilation in Aging and Diabetes, a Neuro-Vascular Damage
title_full_unstemmed Alteration of Pressure-Induced Vasodilation in Aging and Diabetes, a Neuro-Vascular Damage
title_short Alteration of Pressure-Induced Vasodilation in Aging and Diabetes, a Neuro-Vascular Damage
title_sort alteration of pressure-induced vasodilation in aging and diabetes, a neuro-vascular damage
topic Physiology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6616153/
https://www.ncbi.nlm.nih.gov/pubmed/31333501
http://dx.doi.org/10.3389/fphys.2019.00862
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